Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)

Detalhes bibliográficos
Autor(a) principal: Nobre, José Guilherme
Data de Publicação: 2022
Outros Autores: Delgadinho, Mariana, Silva, Carina, Mendes, Joana, Mateus, Vanessa, Ribeiro, Edna, Costa, Diogo Alpuim, Lopes, Miguel, Pedroso, Ana Isabel, Trigueiros, Frederico, Rodrigues, Maria Inês, Sousa, Cristina Lino de, Brito, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/15150
Resumo: FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
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spelling Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)COVID-19DysbiosisMicrobiomeMicrobiotaNext generation sequencingPrognosisRisk stratificationFCT_UIDB/05608/2020FCT_UIDP/05608/2020FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.Background: Gut microbiota is intrinsically associated with the immune system and can promote or suppress infectious diseases, especially viral infections. This study aims to characterize and compare the microbiota profile of infected patients with SARS-CoV-2 (milder or more severe symptoms), non-infected people, and recovered patients. This is a national, transversal, observational, multicenter, and case-control study that analyzed the microbiota of COVID-19 patients with mild or severe symptoms at home, at the hospital, or in the intensive care unit, patients already recovered, and healthy volunteers cohabiting with COVID-19 patients. DNA was isolated from stool samples and sequenced in a NGS platform. A demographic questionnaire was also applied. Statistical analysis was performed in SPSS. Results: Firmicutes/Bacteroidetes ratios were found to be significantly lower in infected patients (1.61 and 2.57) compared to healthy volunteers (3.23) and recovered patients (3.89). Furthermore, the microbiota composition differed significantly between healthy volunteers, mild and severe COVID-19 patients, and recovered patients. Furthermore, Escherichia coli, Actinomyces naeslundii, and Dorea longicatena were shown to be more frequent in severe cases. The most common COVID-19 symptoms were linked to certain microbiome groups. Conclusion: We can conclude that microbiota composition is significantly affected by SARS-CoV-2 infection and may be used to predict COVID-19 clinical evolution. Therefore, it will be possible to better allocate healthcare resources and better tackle future pandemics.The authors acknowledge financial support from Instituto Politécnico de Lisboa which supported this project with the grant Microcovid.Frontiers MediaRCIPLNobre, José GuilhermeDelgadinho, MarianaSilva, CarinaMendes, JoanaMateus, VanessaRibeiro, EdnaCosta, Diogo AlpuimLopes, MiguelPedroso, Ana IsabelTrigueiros, FredericoRodrigues, Maria InêsSousa, Cristina Lino deBrito, Miguel2022-12-14T17:49:56Z2022-112022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/15150engNobre JG, Delgadinho M, Silva C, Mendes J, Mateus V, Ribeiro E, Brito M, et al. Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study). Front Microbiol. 2022;13:1035422.10.3389/fmicb.2022.1035422info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:12:20Zoai:repositorio.ipl.pt:10400.21/15150Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:52.378206Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
title Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
spellingShingle Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
Nobre, José Guilherme
COVID-19
Dysbiosis
Microbiome
Microbiota
Next generation sequencing
Prognosis
Risk stratification
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
title_full Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
title_fullStr Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
title_full_unstemmed Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
title_sort Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)
author Nobre, José Guilherme
author_facet Nobre, José Guilherme
Delgadinho, Mariana
Silva, Carina
Mendes, Joana
Mateus, Vanessa
Ribeiro, Edna
Costa, Diogo Alpuim
Lopes, Miguel
Pedroso, Ana Isabel
Trigueiros, Frederico
Rodrigues, Maria Inês
Sousa, Cristina Lino de
Brito, Miguel
author_role author
author2 Delgadinho, Mariana
Silva, Carina
Mendes, Joana
Mateus, Vanessa
Ribeiro, Edna
Costa, Diogo Alpuim
Lopes, Miguel
Pedroso, Ana Isabel
Trigueiros, Frederico
Rodrigues, Maria Inês
Sousa, Cristina Lino de
Brito, Miguel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Nobre, José Guilherme
Delgadinho, Mariana
Silva, Carina
Mendes, Joana
Mateus, Vanessa
Ribeiro, Edna
Costa, Diogo Alpuim
Lopes, Miguel
Pedroso, Ana Isabel
Trigueiros, Frederico
Rodrigues, Maria Inês
Sousa, Cristina Lino de
Brito, Miguel
dc.subject.por.fl_str_mv COVID-19
Dysbiosis
Microbiome
Microbiota
Next generation sequencing
Prognosis
Risk stratification
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic COVID-19
Dysbiosis
Microbiome
Microbiota
Next generation sequencing
Prognosis
Risk stratification
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-14T17:49:56Z
2022-11
2022-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/15150
url http://hdl.handle.net/10400.21/15150
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nobre JG, Delgadinho M, Silva C, Mendes J, Mateus V, Ribeiro E, Brito M, et al. Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study). Front Microbiol. 2022;13:1035422.
10.3389/fmicb.2022.1035422
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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