Schistosomiasis and infertility: what do we know?
Main Author: | |
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Publication Date: | 2019 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.18/6553 |
Summary: | There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis. |
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Schistosomiasis and infertility: what do we know?Catechol-estrogensEstrogen ReceptorsEstrogensFemale InfertilityMale InfertilitySchistosomiasisThere is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.Highlights: In spite of a plethora of epidemiological evidence supporting a key role for schistosome infection for infertility, little is known about the mechanisms of their association. To date, one of the few well characterized mechanisms by which schistosomes interact with their hosts is the estrogenic imbalance and downregulation of the estrogen receptor. Remarkably, our understanding of this mechanism has already been successfully studied in cancer-associated schistosomiasis. The relentless advancement in molecular studies, together with the discovery of novel biomarkers, provide unprecedented opportunities to investigate schistosomiasis and exploit parasite–host relationships for the development of novel strategies of disease control. There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.ElsevierRepositório Científico do Instituto Nacional de SaúdeRibeiro, Ana RitaLuis, CarlaFernandes, RubenBotelho, Monica C.2020-04-29T05:49:51Z2019-122019-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6553engTrends Parasitol. 2019 Dec;35(12):964-971. doi: 10.1016/j.pt.2019.09.001. Epub 2019 Oct 141471-492210.1016/j.pt.2019.09.001info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:31Zoai:repositorio.insa.pt:10400.18/6553Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:15.661772Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Schistosomiasis and infertility: what do we know? |
title |
Schistosomiasis and infertility: what do we know? |
spellingShingle |
Schistosomiasis and infertility: what do we know? Ribeiro, Ana Rita Catechol-estrogens Estrogen Receptors Estrogens Female Infertility Male Infertility Schistosomiasis |
title_short |
Schistosomiasis and infertility: what do we know? |
title_full |
Schistosomiasis and infertility: what do we know? |
title_fullStr |
Schistosomiasis and infertility: what do we know? |
title_full_unstemmed |
Schistosomiasis and infertility: what do we know? |
title_sort |
Schistosomiasis and infertility: what do we know? |
author |
Ribeiro, Ana Rita |
author_facet |
Ribeiro, Ana Rita Luis, Carla Fernandes, Ruben Botelho, Monica C. |
author_role |
author |
author2 |
Luis, Carla Fernandes, Ruben Botelho, Monica C. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Ribeiro, Ana Rita Luis, Carla Fernandes, Ruben Botelho, Monica C. |
dc.subject.por.fl_str_mv |
Catechol-estrogens Estrogen Receptors Estrogens Female Infertility Male Infertility Schistosomiasis |
topic |
Catechol-estrogens Estrogen Receptors Estrogens Female Infertility Male Infertility Schistosomiasis |
description |
There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12 2019-12-01T00:00:00Z 2020-04-29T05:49:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6553 |
url |
http://hdl.handle.net/10400.18/6553 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Trends Parasitol. 2019 Dec;35(12):964-971. doi: 10.1016/j.pt.2019.09.001. Epub 2019 Oct 14 1471-4922 10.1016/j.pt.2019.09.001 |
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info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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