Are structurally modified galactomannan derivatives biologically active?

Detalhes bibliográficos
Autor(a) principal: Geronço, Maurycyo Silva
Data de Publicação: 2021
Outros Autores: Ramos, Igor Frederico da Silveira, Silva Filho, Edson Cavalcanti da, Rizzo, Márcia dos Santos, Ribeiro, Alessandra Braga, Costa, Marcilia Pinheiro da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/36690
Resumo: Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.
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spelling Are structurally modified galactomannan derivatives biologically active?PolysaccharidesBiopolymerBioactivityDerivatizationGalactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.Veritati - Repositório Institucional da Universidade Católica PortuguesaGeronço, Maurycyo SilvaRamos, Igor Frederico da SilveiraSilva Filho, Edson Cavalcanti daRizzo, Márcia dos SantosRibeiro, Alessandra BragaCosta, Marcilia Pinheiro da2022-02-15T11:40:59Z2021-01-082021-01-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/36690eng2673-417610.3390/polysaccharides201000185120397355info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-19T01:38:02Zoai:repositorio.ucp.pt:10400.14/36690Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:29:49.417038Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Are structurally modified galactomannan derivatives biologically active?
title Are structurally modified galactomannan derivatives biologically active?
spellingShingle Are structurally modified galactomannan derivatives biologically active?
Geronço, Maurycyo Silva
Polysaccharides
Biopolymer
Bioactivity
Derivatization
title_short Are structurally modified galactomannan derivatives biologically active?
title_full Are structurally modified galactomannan derivatives biologically active?
title_fullStr Are structurally modified galactomannan derivatives biologically active?
title_full_unstemmed Are structurally modified galactomannan derivatives biologically active?
title_sort Are structurally modified galactomannan derivatives biologically active?
author Geronço, Maurycyo Silva
author_facet Geronço, Maurycyo Silva
Ramos, Igor Frederico da Silveira
Silva Filho, Edson Cavalcanti da
Rizzo, Márcia dos Santos
Ribeiro, Alessandra Braga
Costa, Marcilia Pinheiro da
author_role author
author2 Ramos, Igor Frederico da Silveira
Silva Filho, Edson Cavalcanti da
Rizzo, Márcia dos Santos
Ribeiro, Alessandra Braga
Costa, Marcilia Pinheiro da
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Geronço, Maurycyo Silva
Ramos, Igor Frederico da Silveira
Silva Filho, Edson Cavalcanti da
Rizzo, Márcia dos Santos
Ribeiro, Alessandra Braga
Costa, Marcilia Pinheiro da
dc.subject.por.fl_str_mv Polysaccharides
Biopolymer
Bioactivity
Derivatization
topic Polysaccharides
Biopolymer
Bioactivity
Derivatization
description Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-08
2021-01-08T00:00:00Z
2022-02-15T11:40:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/36690
url http://hdl.handle.net/10400.14/36690
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2673-4176
10.3390/polysaccharides2010001
85120397355
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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