HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/7839 |
Resumo: | Multicenter Study |
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HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromiumEnvironmental GenotoxicityHuman BiomonitoringOccupational ExposureHexavalent chromiumStandard Operating ProcedureBiological MonitoringHarmonisationMethodologyMulticentreGenotoxicidade AmbientalMulticenter StudyThe EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. As part of HBM4EU, we presented a protocol for a multicentre study to characterize occupational exposure to hexavalent chromium (Cr(VI)) in nine European countries (HBM4EU chromates study). This study intended to collect data on current occupational exposure and to test new indicators for chromium (Cr) biomonitoring (Cr(VI) in exhaled breath condensate and Cr in red blood cells), in addition to traditional urinary total Cr analyses. Also, data from occupational hygiene samples and biomarkers of early biological effects, including genetic and epigenetic effects, was obtained, complementing the biomonitoring information. Data collection and analysis was completed, with the project findings being made separately available. As HBM4EU prepares to embark on further European wide biomonitoring studies, we considered it important to reflect on the experiences gained through our harmonised approach. Several practical aspects are highlighted for improvement in future studies, e.g., more thorough/earlier training on the implementation of standard operating procedures for field researchers, training on the use of the data entry template, as well as improved company communications. The HBM4EU chromates study team considered that the study had successfully demonstrated the feasibility of conducting a harmonised multicentre investigation able to achieve the research aims and objectives. This was largely attributable to the engaged multidisciplinary network, committed to deliver clearly understood goals. Such networks take time and investment to develop, but are priceless in terms of their ability to deliver and facilitate knowledge sharing and collaboration.Highlights: Feasibility of conducting harmonised Pan-European biomonitoring study on occupational exposure demonstrated; Developing a successful network and implementation of systematic methodology takes significant dedication from all involved; Methodological improvements were identified which will benefit future large-scale occupational biomonitoring campaigns; Developed multicentre network allows and promotes further opportunities for future research, knowledge sharing and collaboration; Data produced supports science to policy interface in the scope of REACH and occupational safety and health regulations.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries.Elsevier/ Urban and FischerRepositório Científico do Instituto Nacional de SaúdeGalea, Karen S.Porras, Simo P.Viegas, SusanaBocca, BeatriceBousoumah, RadiaDuca, Radu CorneliuGodderis, LodeIavicoli, IvoJanasik, BeataJones, KateKnudsen, Lisbeth E.Leese, ElizabethLeso, VerusckaLouro, HenriquetaNdaw, SophieRuggieri, FlaviaSepai, OvnairScheepers, Paul T.J.Silva, Maria J.Wasowicz, WojciechSantonen, Tiina2022-01-10T15:40:24Z2021-052021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7839engInt J Hyg Environ Health. 2021 May;234:113725. doi: 10.1016/j.ijheh.2021.113725. Epub 2021 Mar 111438-463910.1016/j.ijheh.2021.113725info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:11Zoai:repositorio.insa.pt:10400.18/7839Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:24.490459Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium |
| title |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium |
| spellingShingle |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium Galea, Karen S. Environmental Genotoxicity Human Biomonitoring Occupational Exposure Hexavalent chromium Standard Operating Procedure Biological Monitoring Harmonisation Methodology Multicentre Genotoxicidade Ambiental |
| title_short |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium |
| title_full |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium |
| title_fullStr |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium |
| title_full_unstemmed |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium |
| title_sort |
HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium |
| author |
Galea, Karen S. |
| author_facet |
Galea, Karen S. Porras, Simo P. Viegas, Susana Bocca, Beatrice Bousoumah, Radia Duca, Radu Corneliu Godderis, Lode Iavicoli, Ivo Janasik, Beata Jones, Kate Knudsen, Lisbeth E. Leese, Elizabeth Leso, Veruscka Louro, Henriqueta Ndaw, Sophie Ruggieri, Flavia Sepai, Ovnair Scheepers, Paul T.J. Silva, Maria J. Wasowicz, Wojciech Santonen, Tiina |
| author_role |
author |
| author2 |
Porras, Simo P. Viegas, Susana Bocca, Beatrice Bousoumah, Radia Duca, Radu Corneliu Godderis, Lode Iavicoli, Ivo Janasik, Beata Jones, Kate Knudsen, Lisbeth E. Leese, Elizabeth Leso, Veruscka Louro, Henriqueta Ndaw, Sophie Ruggieri, Flavia Sepai, Ovnair Scheepers, Paul T.J. Silva, Maria J. Wasowicz, Wojciech Santonen, Tiina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Galea, Karen S. Porras, Simo P. Viegas, Susana Bocca, Beatrice Bousoumah, Radia Duca, Radu Corneliu Godderis, Lode Iavicoli, Ivo Janasik, Beata Jones, Kate Knudsen, Lisbeth E. Leese, Elizabeth Leso, Veruscka Louro, Henriqueta Ndaw, Sophie Ruggieri, Flavia Sepai, Ovnair Scheepers, Paul T.J. Silva, Maria J. Wasowicz, Wojciech Santonen, Tiina |
| dc.subject.por.fl_str_mv |
Environmental Genotoxicity Human Biomonitoring Occupational Exposure Hexavalent chromium Standard Operating Procedure Biological Monitoring Harmonisation Methodology Multicentre Genotoxicidade Ambiental |
| topic |
Environmental Genotoxicity Human Biomonitoring Occupational Exposure Hexavalent chromium Standard Operating Procedure Biological Monitoring Harmonisation Methodology Multicentre Genotoxicidade Ambiental |
| description |
Multicenter Study |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-05 2021-05-01T00:00:00Z 2022-01-10T15:40:24Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/7839 |
| url |
http://hdl.handle.net/10400.18/7839 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Int J Hyg Environ Health. 2021 May;234:113725. doi: 10.1016/j.ijheh.2021.113725. Epub 2021 Mar 11 1438-4639 10.1016/j.ijheh.2021.113725 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier/ Urban and Fischer |
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Elsevier/ Urban and Fischer |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132169482797056 |