Joint dispersion model with a flexible link
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/17914 |
Resumo: | "The objective is to model longitudinal and survival data jointly taking into account the dependence between the two responses in a real HIV/AIDS dataset using a shared parameter approach inside a Bayesian framework. We propose a linear mixed effects dispersion model to adjust the CD4 longitudinal biomarker data with a between-individual heterogeneity in the mean and variance. In doing so we are relaxing the usual assumption of a common variance for the longitudinal residuals. A hazard regression model is considered in addition to model the time since HIV/AIDS diagnostic until failure, being the coefficients, accounting for the linking between the longitudinal and survival processes, time-varying. This flexibility is specified using Penalized Splines and allows the relationship to vary in time. Because heteroscedasticity may be related with the survival, the standard deviation is considered as a covariate in the hazard model, thus enabling to study the effect of the CD4 counts’ stability on the survival. The proposed framework outperforms the most used joint models, highlighting the importance in correctly taking account the individual heterogeneity for the measurement errors variance and the evolution of the disease over time in bringing new insights to better understand this biomarker-survival relation." |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Joint dispersion model with a flexible linkJoint modelBayesian analysisRepeated measurementsVariance modelTime-to-eventPenalized SplinesTime-dependent coefficients"The objective is to model longitudinal and survival data jointly taking into account the dependence between the two responses in a real HIV/AIDS dataset using a shared parameter approach inside a Bayesian framework. We propose a linear mixed effects dispersion model to adjust the CD4 longitudinal biomarker data with a between-individual heterogeneity in the mean and variance. In doing so we are relaxing the usual assumption of a common variance for the longitudinal residuals. A hazard regression model is considered in addition to model the time since HIV/AIDS diagnostic until failure, being the coefficients, accounting for the linking between the longitudinal and survival processes, time-varying. This flexibility is specified using Penalized Splines and allows the relationship to vary in time. Because heteroscedasticity may be related with the survival, the standard deviation is considered as a covariate in the hazard model, thus enabling to study the effect of the CD4 counts’ stability on the survival. The proposed framework outperforms the most used joint models, highlighting the importance in correctly taking account the individual heterogeneity for the measurement errors variance and the evolution of the disease over time in bringing new insights to better understand this biomarker-survival relation."Egas Moniz - Cooperativa de Ensino Superior CRLarXiv.orgRepositório ComumMartins, Rui2017-02-10T11:08:39Z2016-04-01T00:00:00Z2016-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/17914engMartins, R. (2016). Joint dispersion model with a flexible link. arXiv,1604.08853info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:47Zoai:comum.rcaap.pt:10400.26/17914Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:46.687803Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Joint dispersion model with a flexible link |
title |
Joint dispersion model with a flexible link |
spellingShingle |
Joint dispersion model with a flexible link Martins, Rui Joint model Bayesian analysis Repeated measurements Variance model Time-to-event Penalized Splines Time-dependent coefficients |
title_short |
Joint dispersion model with a flexible link |
title_full |
Joint dispersion model with a flexible link |
title_fullStr |
Joint dispersion model with a flexible link |
title_full_unstemmed |
Joint dispersion model with a flexible link |
title_sort |
Joint dispersion model with a flexible link |
author |
Martins, Rui |
author_facet |
Martins, Rui |
author_role |
author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Martins, Rui |
dc.subject.por.fl_str_mv |
Joint model Bayesian analysis Repeated measurements Variance model Time-to-event Penalized Splines Time-dependent coefficients |
topic |
Joint model Bayesian analysis Repeated measurements Variance model Time-to-event Penalized Splines Time-dependent coefficients |
description |
"The objective is to model longitudinal and survival data jointly taking into account the dependence between the two responses in a real HIV/AIDS dataset using a shared parameter approach inside a Bayesian framework. We propose a linear mixed effects dispersion model to adjust the CD4 longitudinal biomarker data with a between-individual heterogeneity in the mean and variance. In doing so we are relaxing the usual assumption of a common variance for the longitudinal residuals. A hazard regression model is considered in addition to model the time since HIV/AIDS diagnostic until failure, being the coefficients, accounting for the linking between the longitudinal and survival processes, time-varying. This flexibility is specified using Penalized Splines and allows the relationship to vary in time. Because heteroscedasticity may be related with the survival, the standard deviation is considered as a covariate in the hazard model, thus enabling to study the effect of the CD4 counts’ stability on the survival. The proposed framework outperforms the most used joint models, highlighting the importance in correctly taking account the individual heterogeneity for the measurement errors variance and the evolution of the disease over time in bringing new insights to better understand this biomarker-survival relation." |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-01T00:00:00Z 2016-04-01T00:00:00Z 2017-02-10T11:08:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/17914 |
url |
http://hdl.handle.net/10400.26/17914 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Martins, R. (2016). Joint dispersion model with a flexible link. arXiv,1604.08853 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
arXiv.org |
publisher.none.fl_str_mv |
arXiv.org |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799129955649454080 |