Regression splines in the time-dependent coefficient rates model for recurrent event data

Detalhes bibliográficos
Autor(a) principal: Amorim, Leila Denise Alves Ferreira
Data de Publicação: 2008
Outros Autores: Cai, Jianwen, Zeng, Donglin, Barreto, Mauricio Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13732
Resumo: Texto completo: acesso restrito. p. 5890-5906
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spelling Amorim, Leila Denise Alves FerreiraCai, JianwenZeng, DonglinBarreto, Mauricio LimaAmorim, Leila Denise Alves FerreiraCai, JianwenZeng, DonglinBarreto, Mauricio Lima2013-11-19T14:13:15Z20080277-6715http://repositorio.ufba.br/ri/handle/ri/13732v. 27, n. 28Texto completo: acesso restrito. p. 5890-5906Many epidemiologic studies involve the occurrence of recurrent events and much attention has been given for the development of modeling techniques that take into account the dependence structure of multiple event data. This paper presents a time-dependent coefficient rates model that incorporates regression splines in its estimation procedure. Such methods would be appropriate in situations where the effect of an exposure or covariates changes over time in recurrent event data settings. The finite sample properties of the estimators are studied via simulation. Using data from a randomized community trial that was designed to evaluate the effect of vitamin A supplementation on recurrent diarrheal episodes in small children, we model the functional form of the treatment effect on the time to the occurrence of diarrhea. The results describe how this effect varies over time. In summary, we observed a major impact of the vitamin A supplementation on diarrhea after 2 months of the dosage, with the effect diminishing after the third dosage. The proposed method can be viewed as a flexible alternative to the marginal rates model with constant effect in situations where the effect of interest may vary over time.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-19T14:13:15Z No. of bitstreams: 1 10.1002-sim.3400.pdf: 181138 bytes, checksum: 0e846ea7fb1f49fc09b2499df09fb226 (MD5)Made available in DSpace on 2013-11-19T14:13:15Z (GMT). No. of bitstreams: 1 10.1002-sim.3400.pdf: 181138 bytes, checksum: 0e846ea7fb1f49fc09b2499df09fb226 (MD5) Previous issue date: 2008http://dx.doi.org/10.1002/sim.3400reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBARegression splinesRecurrent time-to-event dataTime-dependent coefficientMarginal rates modelRegression splines in the time-dependent coefficient rates model for recurrent event dataStatistics in Medicineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1002-sim.3400.pdf10.1002-sim.3400.pdfapplication/pdf181138https://repositorio.ufba.br/bitstream/ri/13732/1/10.1002-sim.3400.pdf0e846ea7fb1f49fc09b2499df09fb226MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13732/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1002-sim.3400.pdf.txt10.1002-sim.3400.pdf.txtExtracted texttext/plain51942https://repositorio.ufba.br/bitstream/ri/13732/3/10.1002-sim.3400.pdf.txt57918d0861c53bb49a03b1c623833bc2MD53ri/137322022-08-08 13:17:27.832oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Regression splines in the time-dependent coefficient rates model for recurrent event data
dc.title.alternative.pt_BR.fl_str_mv Statistics in Medicine
title Regression splines in the time-dependent coefficient rates model for recurrent event data
spellingShingle Regression splines in the time-dependent coefficient rates model for recurrent event data
Amorim, Leila Denise Alves Ferreira
Regression splines
Recurrent time-to-event data
Time-dependent coefficient
Marginal rates model
title_short Regression splines in the time-dependent coefficient rates model for recurrent event data
title_full Regression splines in the time-dependent coefficient rates model for recurrent event data
title_fullStr Regression splines in the time-dependent coefficient rates model for recurrent event data
title_full_unstemmed Regression splines in the time-dependent coefficient rates model for recurrent event data
title_sort Regression splines in the time-dependent coefficient rates model for recurrent event data
author Amorim, Leila Denise Alves Ferreira
author_facet Amorim, Leila Denise Alves Ferreira
Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
author_role author
author2 Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
author2_role author
author
author
dc.contributor.author.fl_str_mv Amorim, Leila Denise Alves Ferreira
Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
Amorim, Leila Denise Alves Ferreira
Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
dc.subject.por.fl_str_mv Regression splines
Recurrent time-to-event data
Time-dependent coefficient
Marginal rates model
topic Regression splines
Recurrent time-to-event data
Time-dependent coefficient
Marginal rates model
description Texto completo: acesso restrito. p. 5890-5906
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-11-19T14:13:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13732
dc.identifier.issn.none.fl_str_mv 0277-6715
dc.identifier.number.pt_BR.fl_str_mv v. 27, n. 28
identifier_str_mv 0277-6715
v. 27, n. 28
url http://repositorio.ufba.br/ri/handle/ri/13732
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1002/sim.3400
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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