Biomarkers in functional movement disorders : a systematic review

Detalhes bibliográficos
Autor(a) principal: Thomsen, Birgitte Liang Chen
Data de Publicação: 2020
Outros Autores: Teodoro, Tiago, Edwards, Mark J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47311
Resumo: © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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spelling Biomarkers in functional movement disorders : a systematic reviewEEGEMGFunctional imagingFunctional neurological disorderMovement disorders© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.Functional movement disorders (FMD) are proposed to reflect a specific problem with voluntary control of movement, despite normal intent to move and an intact neural capacity for movement. In many cases, a positive diagnosis of FMD can be established on clinical grounds. However, the diagnosis remains challenging in certain scenarios, and there is a need for predictors of treatment response and long-term prognosis.In this context, we performed a systematic review of biomarkers in FMD. Eighty-six studies met our predefined criteria and were included.We found fairly reliable electroencephalography and electromyography-based diagnostic biomarkers for functional myoclonus and tremor. Promising biomarkers have also been described for functional paresis, gait and balance disorders. In contrast, there is still a lack of diagnostic biomarkers of functional dystonia and tics, where clinical diagnosis is often also more challenging. Importantly, many promising findings focus on pathophysiology and reflect group-level comparisons, but cannot differentiate on an individual basis. Some biomarkers also require access to time-consuming and resource-consuming techniques such as functional MRI.In conclusion, there are important gaps in diagnostic biomarkers in FMD in the areas of most clinical uncertainty. There is also is a lack of treatment response and prognostic biomarkers to aid in the selection of patients who would benefit from rehabilitation and other forms of treatment.BMJ Publishing Group, Ltd.Repositório da Universidade de LisboaThomsen, Birgitte Liang ChenTeodoro, TiagoEdwards, Mark J.2021-04-09T12:38:11Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47311engJ Neurol Neurosurg Psychiatry. 2020 Dec;91(12):1261-12690022-305010.1136/jnnp-2020-3231411468-330Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:09Zoai:repositorio.ul.pt:10451/47311Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:23.156441Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biomarkers in functional movement disorders : a systematic review
title Biomarkers in functional movement disorders : a systematic review
spellingShingle Biomarkers in functional movement disorders : a systematic review
Thomsen, Birgitte Liang Chen
EEG
EMG
Functional imaging
Functional neurological disorder
Movement disorders
title_short Biomarkers in functional movement disorders : a systematic review
title_full Biomarkers in functional movement disorders : a systematic review
title_fullStr Biomarkers in functional movement disorders : a systematic review
title_full_unstemmed Biomarkers in functional movement disorders : a systematic review
title_sort Biomarkers in functional movement disorders : a systematic review
author Thomsen, Birgitte Liang Chen
author_facet Thomsen, Birgitte Liang Chen
Teodoro, Tiago
Edwards, Mark J.
author_role author
author2 Teodoro, Tiago
Edwards, Mark J.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Thomsen, Birgitte Liang Chen
Teodoro, Tiago
Edwards, Mark J.
dc.subject.por.fl_str_mv EEG
EMG
Functional imaging
Functional neurological disorder
Movement disorders
topic EEG
EMG
Functional imaging
Functional neurological disorder
Movement disorders
description © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-09T12:38:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47311
url http://hdl.handle.net/10451/47311
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neurol Neurosurg Psychiatry. 2020 Dec;91(12):1261-1269
0022-3050
10.1136/jnnp-2020-323141
1468-330X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group, Ltd.
publisher.none.fl_str_mv BMJ Publishing Group, Ltd.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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