Contingent negative variation: a biomarker of abnormal attention in functional movement disorders
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/50424 |
Resumo: | © 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Contingent negative variation: a biomarker of abnormal attention in functional movement disordersBiomarkersFunctional neurological disordersFunctional movement disordersPsychogenic disorders© 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Background and purpose: Contingent negative variation (CNV) is a negative cortical wave that precedes a pre-cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV. Methods: Motor performance and CNV were analysed during a pre-cued choice reaction time task with varying cue validity. Twenty-one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow-up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non-responders) and retested. Results: At baseline, patients did not generate CNV, contrary to controls [mean amplitude (µV) at the end of preparation to move: patients -0.47 (95% CI -1.94, 1.00) versus controls -2.59 (95% CI -4.46, -0.72)]. Responders performed faster after physiotherapy [mean natural logarithm (ln) reaction time (RT) (ms): follow-up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non-responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow-up -1.95 (95% CI -3.49, -0.41) versus baseline -0.19 (95% CI -1.73, 1.35), P < 0.001], contrary to non-responders [follow-up -0.32 (95% CI -1.79, 1.14) versus baseline -0.72 (95% CI -2.19, 0.75), P = 0.381]. Conclusions: Clinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders.This study was supported by the Medical Research Council (UK). Glenn Nielsen and Mark J Edwards received research funding from the National Institute for Health Research. Simon Little was funded by a clinical research training grant from the Wellcome Trust (105804/Z/14/Z).WileyRepositório da Universidade de LisboaTeodoro, TiagoKoreki, A.Meppelink, A. M.Little, S.Nielsen, G.Macerollo, A.Ferreira, Joaquim JPareés, I.Lang, A.Edwards, M. J.2021-12-15T15:38:57Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50424engEur J Neurol. 2020 Jun;27(6):985-9941351-510110.1111/ene.141891468-1331info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:35Zoai:repositorio.ul.pt:10451/50424Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:53.085455Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders |
| title |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders |
| spellingShingle |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders Teodoro, Tiago Biomarkers Functional neurological disorders Functional movement disorders Psychogenic disorders |
| title_short |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders |
| title_full |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders |
| title_fullStr |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders |
| title_full_unstemmed |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders |
| title_sort |
Contingent negative variation: a biomarker of abnormal attention in functional movement disorders |
| author |
Teodoro, Tiago |
| author_facet |
Teodoro, Tiago Koreki, A. Meppelink, A. M. Little, S. Nielsen, G. Macerollo, A. Ferreira, Joaquim J Pareés, I. Lang, A. Edwards, M. J. |
| author_role |
author |
| author2 |
Koreki, A. Meppelink, A. M. Little, S. Nielsen, G. Macerollo, A. Ferreira, Joaquim J Pareés, I. Lang, A. Edwards, M. J. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Teodoro, Tiago Koreki, A. Meppelink, A. M. Little, S. Nielsen, G. Macerollo, A. Ferreira, Joaquim J Pareés, I. Lang, A. Edwards, M. J. |
| dc.subject.por.fl_str_mv |
Biomarkers Functional neurological disorders Functional movement disorders Psychogenic disorders |
| topic |
Biomarkers Functional neurological disorders Functional movement disorders Psychogenic disorders |
| description |
© 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-12-15T15:38:57Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50424 |
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http://hdl.handle.net/10451/50424 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Eur J Neurol. 2020 Jun;27(6):985-994 1351-5101 10.1111/ene.14189 1468-1331 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134567709278208 |