In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications

Detalhes bibliográficos
Autor(a) principal: Martins, E.
Data de Publicação: 2023
Outros Autores: Reis, R. L., Silva, Tiago H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/82350
Resumo: The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels.
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spelling In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applicationscytotoxicityFish by-productshydrationhydrogelin vivo assaymarine collagenskin cosmetic formulationScience & TechnologyThe industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels.The authors acknowledge the funding from the European Union Transborder Cooperation Programme Interreg España-Portugal 2014–2020 (POCTEP) under the project 0302_CVMAR_I_1_P, which supported also the cosmetic clinical study performed by INOVAPOTEK under a services acquisition contract.MDPIUniversidade do MinhoMartins, E.Reis, R. L.Silva, Tiago H.2023-012023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/82350engMartins, E.; Reis, R.L.; Silva, T.H. In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications. Mar. Drugs 2023, 21, 57. https://doi.org/10.3390/md210200571660-339710.3390/md2102005736827098https://www.mdpi.com/1660-3397/21/2/57info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:47Zoai:repositorium.sdum.uminho.pt:1822/82350Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:29:21.083195Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
title In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
spellingShingle In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
Martins, E.
cytotoxicity
Fish by-products
hydration
hydrogel
in vivo assay
marine collagen
skin cosmetic formulation
Science & Technology
title_short In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
title_full In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
title_fullStr In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
title_full_unstemmed In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
title_sort In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
author Martins, E.
author_facet Martins, E.
Reis, R. L.
Silva, Tiago H.
author_role author
author2 Reis, R. L.
Silva, Tiago H.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Martins, E.
Reis, R. L.
Silva, Tiago H.
dc.subject.por.fl_str_mv cytotoxicity
Fish by-products
hydration
hydrogel
in vivo assay
marine collagen
skin cosmetic formulation
Science & Technology
topic cytotoxicity
Fish by-products
hydration
hydrogel
in vivo assay
marine collagen
skin cosmetic formulation
Science & Technology
description The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/82350
url https://hdl.handle.net/1822/82350
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins, E.; Reis, R.L.; Silva, T.H. In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications. Mar. Drugs 2023, 21, 57. https://doi.org/10.3390/md21020057
1660-3397
10.3390/md21020057
36827098
https://www.mdpi.com/1660-3397/21/2/57
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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