Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation

Detalhes bibliográficos
Autor(a) principal: Barvitenko, Nadezhda
Data de Publicação: 2022
Outros Autores: Ashrafuzzaman, Mohammad, Lawen, Alfons, Skverchinskaya, Elisaveta, Saldanha, Carlota, Manca, Alessia, Uras, Giuseppe, Aslam, Muhammad, Pantaleo, Antonella
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52659
Resumo: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammationAtherosclerosisCytoskeletonEndothelial cellInflammationLipid bilayerMechanosensorOxidative stressShear stress© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Chronic low-grade vascular inflammation and endothelial dysfunction significantly contribute to the pathogenesis of cardiovascular diseases. In endothelial cells (ECs), anti-inflammatory or pro-inflammatory signaling can be induced by different patterns of the fluid shear stress (SS) exerted by blood flow on ECs. Laminar blood flow with high magnitude is anti-inflammatory, while disturbed flow and laminar flow with low magnitude is pro-inflammatory. Endothelial mechanosensors are the key upstream signaling proteins in SS-induced pro- and anti-inflammatory responses. Being transmembrane proteins, mechanosensors, not only experience fluid SS but also become regulated by the biomechanical properties of the lipid bilayer and the cytoskeleton. We review the apparent effects of pro-inflammatory factors (hypoxia, oxidative stress, hypercholesterolemia, and cytokines) on the biomechanics of the lipid bilayer and the cytoskeleton. An analysis of the available data suggests that the formation of a vicious circle may occur, in which pro-inflammatory cytokines enhance and attenuate SS-induced pro-inflammatory and anti-inflammatory signaling, respectively.This research was funded by grant from “Fondo di Ateneo per la ricerca 2020”, University of Sassari, Italy.MDPIRepositório da Universidade de LisboaBarvitenko, NadezhdaAshrafuzzaman, MohammadLawen, AlfonsSkverchinskaya, ElisavetaSaldanha, CarlotaManca, AlessiaUras, GiuseppeAslam, MuhammadPantaleo, Antonella2022-05-03T14:22:13Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52659engMembranes 2022, 12, 20510.3390/membranes120202052077-0375info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:00Zoai:repositorio.ul.pt:10451/52659Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:43.288483Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
title Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
spellingShingle Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
Barvitenko, Nadezhda
Atherosclerosis
Cytoskeleton
Endothelial cell
Inflammation
Lipid bilayer
Mechanosensor
Oxidative stress
Shear stress
title_short Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
title_full Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
title_fullStr Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
title_full_unstemmed Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
title_sort Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation
author Barvitenko, Nadezhda
author_facet Barvitenko, Nadezhda
Ashrafuzzaman, Mohammad
Lawen, Alfons
Skverchinskaya, Elisaveta
Saldanha, Carlota
Manca, Alessia
Uras, Giuseppe
Aslam, Muhammad
Pantaleo, Antonella
author_role author
author2 Ashrafuzzaman, Mohammad
Lawen, Alfons
Skverchinskaya, Elisaveta
Saldanha, Carlota
Manca, Alessia
Uras, Giuseppe
Aslam, Muhammad
Pantaleo, Antonella
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Barvitenko, Nadezhda
Ashrafuzzaman, Mohammad
Lawen, Alfons
Skverchinskaya, Elisaveta
Saldanha, Carlota
Manca, Alessia
Uras, Giuseppe
Aslam, Muhammad
Pantaleo, Antonella
dc.subject.por.fl_str_mv Atherosclerosis
Cytoskeleton
Endothelial cell
Inflammation
Lipid bilayer
Mechanosensor
Oxidative stress
Shear stress
topic Atherosclerosis
Cytoskeleton
Endothelial cell
Inflammation
Lipid bilayer
Mechanosensor
Oxidative stress
Shear stress
description © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2022
dc.date.none.fl_str_mv 2022-05-03T14:22:13Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52659
url http://hdl.handle.net/10451/52659
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Membranes 2022, 12, 205
10.3390/membranes12020205
2077-0375
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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