An overview of molecular basis of iron metabolism regulation and the associated pathologies

Detalhes bibliográficos
Autor(a) principal: Silva, Bruno
Data de Publicação: 2015
Outros Autores: Faustino, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/3110
Resumo: Iron is essential for several vital biological processes. Its deficiency or overload drive to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, as the alternative splicing, microRNAs, the IRP/IREs system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.
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spelling An overview of molecular basis of iron metabolism regulation and the associated pathologiesIron MetabolismIron OverloadIronHFEHepcidinHereditary HaemochromatosisHemochromatosisAnaemiaPost-transcriptional regulationDoenças GenéticasIron is essential for several vital biological processes. Its deficiency or overload drive to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, as the alternative splicing, microRNAs, the IRP/IREs system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.BS was financially supported by SFRH/BD/60718/2009; This work was partially funded by Pest-OE/SAU/UI0009/2013.ElsevierRepositório Científico do Instituto Nacional de SaúdeSilva, BrunoFaustino, Paula2015-09-17T11:38:46Z2015-072015-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3110engBiochim Biophys Acta. 2015 Jul;1852(7):1347-59. doi: 10.1016/j.bbadis.2015.03.011. Epub 2015 Apr 20006-300210.1016/j.bbadis.2015.03.011info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:34Zoai:repositorio.insa.pt:10400.18/3110Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:58.463273Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An overview of molecular basis of iron metabolism regulation and the associated pathologies
title An overview of molecular basis of iron metabolism regulation and the associated pathologies
spellingShingle An overview of molecular basis of iron metabolism regulation and the associated pathologies
Silva, Bruno
Iron Metabolism
Iron Overload
Iron
HFE
Hepcidin
Hereditary Haemochromatosis
Hemochromatosis
Anaemia
Post-transcriptional regulation
Doenças Genéticas
title_short An overview of molecular basis of iron metabolism regulation and the associated pathologies
title_full An overview of molecular basis of iron metabolism regulation and the associated pathologies
title_fullStr An overview of molecular basis of iron metabolism regulation and the associated pathologies
title_full_unstemmed An overview of molecular basis of iron metabolism regulation and the associated pathologies
title_sort An overview of molecular basis of iron metabolism regulation and the associated pathologies
author Silva, Bruno
author_facet Silva, Bruno
Faustino, Paula
author_role author
author2 Faustino, Paula
author2_role author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Silva, Bruno
Faustino, Paula
dc.subject.por.fl_str_mv Iron Metabolism
Iron Overload
Iron
HFE
Hepcidin
Hereditary Haemochromatosis
Hemochromatosis
Anaemia
Post-transcriptional regulation
Doenças Genéticas
topic Iron Metabolism
Iron Overload
Iron
HFE
Hepcidin
Hereditary Haemochromatosis
Hemochromatosis
Anaemia
Post-transcriptional regulation
Doenças Genéticas
description Iron is essential for several vital biological processes. Its deficiency or overload drive to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, as the alternative splicing, microRNAs, the IRP/IREs system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-17T11:38:46Z
2015-07
2015-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/3110
url http://hdl.handle.net/10400.18/3110
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochim Biophys Acta. 2015 Jul;1852(7):1347-59. doi: 10.1016/j.bbadis.2015.03.011. Epub 2015 Apr 2
0006-3002
10.1016/j.bbadis.2015.03.011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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