Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy

• Autor(a) principal: Aktar, Nasrin
• Data de Publicação: 2022
• Outros Autores: Yueting, Chen, Abbas, Muhammad, Zafar, Hajra, Paiva-Santos, Ana Cláudia, Zhang, Qin, Chen, Tingting, Ahmed, Moudud, Raza, Faisal, Zhou, Xiaohui
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/103345; https://doi.org/10.1155/2022/8901326

Tumor immune escape has emerged as the most significant barrier to cancer therapy. A thorough understanding of tumor immune escape therapy mechanisms is critical for further improving clinical treatment strategies. Currently, research indicates that combining several immunotherapies can boost antitumor efficacy and encourage T cells to play a more active part in the immune assault. To generate a more substantial therapeutic impact, it can establish an ideal tumor microenvironment (TME), encourage T cells to play a role, prevent T cell immune function reversal, and minimize tumor immune tolerance. In this review, we will examine the mechanisms of tumor immune escape and the limits of tumor immune escape therapy, focusing on the current development of immunotherapy based on tumor immune escape mechanisms. Individualized tumor treatment is becoming increasingly apparent as future treatment strategies. In addition, we forecast the future research direction of cancer and the clinical approach for cancer immunotherapy. It will serve as a better reference for researchers working in cancer therapy research.