T2DM animal model shows cortical and hippocampal proteome remodeling

• Autor(a) principal: Cortez, Adriana Carvalho
• Data de Publicação: 2022
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10773/37882
• topic: Type 2 diabetes mellitus; Proteomics; HFD; STZ; KEGG; Neuronal function; Synaptic plasticity

Type 2 Diabetes Mellitus is a heterogenous metabolic disorder that causes several complications to human health. T2DM is caused by a combination of two primary factors: defective insulin secretion by pancreatic cells and inability to respond by insulin-dependent tissues. The presence of T2DM increases the risk of cognitive decline and dementia and has some characteristics similar to Alzheimer’s and Parkinson’s diseases. Thus, it is necessary to understand how T2DM is associated with cerebral complications and neurodegeneration. Proteomics is a very promising area for the study of complications associated with T2DM, allowing the study of altered proteins before and during the disease. This work allowed an update of the knowledge of T2DM and the alterations caused in the brain, as well as to highlight the importance of the research of biomarkers that can predict and/or diagnose the appearance of cognitive alterations. From the geneontology analysis (GO), it was possible to identify some significant biological processes associated with synaptic function. It was also possible to identify which proteins may be dysregulated under HFD and HFD+STZ conditions.