Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents

Detalhes bibliográficos
Autor(a) principal: Ferreira, Fernanda M.
Data de Publicação: 2003
Outros Autores: Seiça, Raquel, Oliveira, Paulo J., Coxito, Pedro M., Moreno, António J., Palmeira, Carlos M., Santos, Maria S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/4799
https://doi.org/10.1016/j.bbadis.2003.08.001
Resumo: Several studies have been carried out to evaluate the alterations in mitochondrial functions of diabetic rats. However, results are sometimes controversial, since experimental conditions diverge, including age and strain of used animals. The purpose of this study was to evaluate the metabolic modifications in liver mitochondria, both in the presence of severe (STZ-treated rats) and mild hyperglycaemia [Goto-Kakizaki (GK) rats], when compared with control animals of similar age. Moreover, metabolic alterations were evaluated also at initial and advanced stages of the disease.
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spelling Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contentsDiabetes mellitusType 1 diabetesType 2 diabetesGoto-Kakizaki (GK) ratStreptozotocin-induced diabetic (STZ) ratMitochondrial permeability transition (MPT)Several studies have been carried out to evaluate the alterations in mitochondrial functions of diabetic rats. However, results are sometimes controversial, since experimental conditions diverge, including age and strain of used animals. The purpose of this study was to evaluate the metabolic modifications in liver mitochondria, both in the presence of severe (STZ-treated rats) and mild hyperglycaemia [Goto-Kakizaki (GK) rats], when compared with control animals of similar age. Moreover, metabolic alterations were evaluated also at initial and advanced stages of the disease.http://www.sciencedirect.com/science/article/B6T1Y-49FPHJH-1/1/3b97418b61eef86377c47c0fc15ca3d12003info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4799http://hdl.handle.net/10316/4799https://doi.org/10.1016/j.bbadis.2003.08.001engBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1639:2 (2003) 113-120Ferreira, Fernanda M.Seiça, RaquelOliveira, Paulo J.Coxito, Pedro M.Moreno, António J.Palmeira, Carlos M.Santos, Maria S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-07T10:32:19Zoai:estudogeral.uc.pt:10316/4799Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:28.069647Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
title Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
spellingShingle Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
Ferreira, Fernanda M.
Diabetes mellitus
Type 1 diabetes
Type 2 diabetes
Goto-Kakizaki (GK) rat
Streptozotocin-induced diabetic (STZ) rat
Mitochondrial permeability transition (MPT)
title_short Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
title_full Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
title_fullStr Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
title_full_unstemmed Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
title_sort Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
author Ferreira, Fernanda M.
author_facet Ferreira, Fernanda M.
Seiça, Raquel
Oliveira, Paulo J.
Coxito, Pedro M.
Moreno, António J.
Palmeira, Carlos M.
Santos, Maria S.
author_role author
author2 Seiça, Raquel
Oliveira, Paulo J.
Coxito, Pedro M.
Moreno, António J.
Palmeira, Carlos M.
Santos, Maria S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Fernanda M.
Seiça, Raquel
Oliveira, Paulo J.
Coxito, Pedro M.
Moreno, António J.
Palmeira, Carlos M.
Santos, Maria S.
dc.subject.por.fl_str_mv Diabetes mellitus
Type 1 diabetes
Type 2 diabetes
Goto-Kakizaki (GK) rat
Streptozotocin-induced diabetic (STZ) rat
Mitochondrial permeability transition (MPT)
topic Diabetes mellitus
Type 1 diabetes
Type 2 diabetes
Goto-Kakizaki (GK) rat
Streptozotocin-induced diabetic (STZ) rat
Mitochondrial permeability transition (MPT)
description Several studies have been carried out to evaluate the alterations in mitochondrial functions of diabetic rats. However, results are sometimes controversial, since experimental conditions diverge, including age and strain of used animals. The purpose of this study was to evaluate the metabolic modifications in liver mitochondria, both in the presence of severe (STZ-treated rats) and mild hyperglycaemia [Goto-Kakizaki (GK) rats], when compared with control animals of similar age. Moreover, metabolic alterations were evaluated also at initial and advanced stages of the disease.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/4799
http://hdl.handle.net/10316/4799
https://doi.org/10.1016/j.bbadis.2003.08.001
url http://hdl.handle.net/10316/4799
https://doi.org/10.1016/j.bbadis.2003.08.001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1639:2 (2003) 113-120
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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