Photocurable Polymeric Blends for Surgical Application

Detalhes bibliográficos
Autor(a) principal: Cernadas, Teresa
Data de Publicação: 2020
Outros Autores: Santos, Marta, Miguel, Sónia P., Correia, I.J., Alves, Patrícia, Ferreira, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/11050
Resumo: The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.
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spelling Photocurable Polymeric Blends for Surgical ApplicationPhotocuringPolymeric blendsBioadhesiveBiocompatibilityAntibacterial activityThe preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.MDPIuBibliorumCernadas, TeresaSantos, MartaMiguel, Sónia P.Correia, I.J.Alves, PatríciaFerreira, Paula2021-01-21T17:00:06Z2020-12-122020-12-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/11050eng10.3390/ma13245681info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:53:11Zoai:ubibliorum.ubi.pt:10400.6/11050Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:50:54.882923Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Photocurable Polymeric Blends for Surgical Application
title Photocurable Polymeric Blends for Surgical Application
spellingShingle Photocurable Polymeric Blends for Surgical Application
Cernadas, Teresa
Photocuring
Polymeric blends
Bioadhesive
Biocompatibility
Antibacterial activity
title_short Photocurable Polymeric Blends for Surgical Application
title_full Photocurable Polymeric Blends for Surgical Application
title_fullStr Photocurable Polymeric Blends for Surgical Application
title_full_unstemmed Photocurable Polymeric Blends for Surgical Application
title_sort Photocurable Polymeric Blends for Surgical Application
author Cernadas, Teresa
author_facet Cernadas, Teresa
Santos, Marta
Miguel, Sónia P.
Correia, I.J.
Alves, Patrícia
Ferreira, Paula
author_role author
author2 Santos, Marta
Miguel, Sónia P.
Correia, I.J.
Alves, Patrícia
Ferreira, Paula
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Cernadas, Teresa
Santos, Marta
Miguel, Sónia P.
Correia, I.J.
Alves, Patrícia
Ferreira, Paula
dc.subject.por.fl_str_mv Photocuring
Polymeric blends
Bioadhesive
Biocompatibility
Antibacterial activity
topic Photocuring
Polymeric blends
Bioadhesive
Biocompatibility
Antibacterial activity
description The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12
2020-12-12T00:00:00Z
2021-01-21T17:00:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/11050
url http://hdl.handle.net/10400.6/11050
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3390/ma13245681
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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