Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma

Detalhes bibliográficos
Autor(a) principal: Nascimento, Catarina
Data de Publicação: 2021
Outros Autores: Gameiro, Andreia, Ferreira, João, Correia, Jorge, Ferreira, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46251
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinomaFeline mammary carcinomaVEGF-AVEGFR-1VEGFR-2Non-invasive biomarkersAngiogenesis© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Vascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR-1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these molecules in tumor-infiltrating lymphocytes (TILs) and in cancer cells was evaluated and compared with its serum levels. Results obtained showed that serum VEGF-A levels were significantly higher in cats with HER2-positive and Triple Negative (TN) Normal-Like subtypes, when compared to control group (p = 0.001, p = 0.020). Additionally, serum VEGFR-1 levels were significantly elevated in cats presenting luminal A, HER2-positive and TN Normal-Like tumors (p = 0.011, p = 0.048, p = 0.006), as serum VEGFR-2 levels (p = 0.010, p = 0.046, p = 0.005). Moreover, a positive interaction was found between the expression of VEGF-A, VEGFR-1, and VEGFR-2 in TILs and their serum levels (p = 0.002, p = 0.003, p = 0.003). In summary, these findings point to the usefulness of VEGF-A and its serum receptors assessment in clinical evaluation of cats with HER2-positive and TN Normal-Like tumors, suggesting that targeted therapies against these molecules may be effective for the treatment of these animals, as described in human breast cancer.This research was funded by Fundação para a Ciência e a Tecnologia (Portugal), through the projects PTDC/CVT-EPI/3638/2014 and UIDB/00276/2020. C.N. is receipt of a PhD fellowship from University of Lisbon (ref.C00191r) and A.G. is receipt of a PhD fellowship from Fundação para a Ciência e a Tecnologia (ref. SFRH/BD/132260/2017).MDPIRepositório da Universidade de LisboaNascimento, CatarinaGameiro, AndreiaFerreira, JoãoCorreia, JorgeFerreira, Fernando2021-02-09T17:20:18Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46251engCancers 2021, 13, 11710.3390/cancers130101172072-6694info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:03:16Zoai:repositorio.ul.pt:10451/46251Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:03:16Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
title Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
spellingShingle Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
Nascimento, Catarina
Feline mammary carcinoma
VEGF-A
VEGFR-1
VEGFR-2
Non-invasive biomarkers
Angiogenesis
title_short Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
title_full Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
title_fullStr Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
title_full_unstemmed Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
title_sort Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
author Nascimento, Catarina
author_facet Nascimento, Catarina
Gameiro, Andreia
Ferreira, João
Correia, Jorge
Ferreira, Fernando
author_role author
author2 Gameiro, Andreia
Ferreira, João
Correia, Jorge
Ferreira, Fernando
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Nascimento, Catarina
Gameiro, Andreia
Ferreira, João
Correia, Jorge
Ferreira, Fernando
dc.subject.por.fl_str_mv Feline mammary carcinoma
VEGF-A
VEGFR-1
VEGFR-2
Non-invasive biomarkers
Angiogenesis
topic Feline mammary carcinoma
VEGF-A
VEGFR-1
VEGFR-2
Non-invasive biomarkers
Angiogenesis
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-02-09T17:20:18Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46251
url http://hdl.handle.net/10451/46251
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cancers 2021, 13, 117
10.3390/cancers13010117
2072-6694
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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