Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/23477 |
Resumo: | Research Areas: Oncology |
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7160 |
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Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinomaFeline mammary carcinomaVEGF-AVEGFR-1VEGFR-2Non-invasive biomarkersAngiogenesisResearch Areas: OncologyVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these molecules in tumor-infiltrating lymphocytes (TILs) and in cancer cells was evaluated and compared with its serum levels. Results obtained showed that serum VEGF-A levels were significantly higher in cats with HER2-positive and Triple Negative (TN) Normal-Like subtypes, when compared to control group (p = 0.001, p = 0.020). Additionally, serum VEGFR-1 levels were significantly elevated in cats presenting luminal A, HER2-positive and TN Normal-Like tumors (p = 0.011, p = 0.048, p = 0.006), as serum VEGFR-2 levels (p = 0.010, p = 0.046, p = 0.005). Moreover, a positive interaction was found between the expression of VEGF-A, VEGFR-1, and VEGFR-2 in TILs and their serum levels (p = 0.002, p = 0.003, p = 0.003). In summary, these findings point to the usefulness of VEGF-A and its serum receptors assessment in clinical evaluation of cats with HER2-positive and TN Normal-Like tumors, suggesting that targeted therapies against these molecules may be effective for the treatment of these animals, as described in human breast cancer.MDPIRepositório da Universidade de LisboaNascimento, CatarinaGameiro, AndreiaFerreira, FernandoCorreia, Jorge Manuel de JesusFerreira, João2022-02-13T22:57:13Z2021-01-012021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/23477engNascimento C, Gameiro A, Ferreira J, Correia J, Ferreira F. 2021. Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma. Cancers, 13(1):117. Doi: 10.3390/cancers1301011710.3390/cancers130101172072-6694info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:00Zoai:www.repository.utl.pt:10400.5/23477Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:07:40.779132Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma |
title |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma |
spellingShingle |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma Nascimento, Catarina Feline mammary carcinoma VEGF-A VEGFR-1 VEGFR-2 Non-invasive biomarkers Angiogenesis |
title_short |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma |
title_full |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma |
title_fullStr |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma |
title_full_unstemmed |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma |
title_sort |
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma |
author |
Nascimento, Catarina |
author_facet |
Nascimento, Catarina Gameiro, Andreia Ferreira, Fernando Correia, Jorge Manuel de Jesus Ferreira, João |
author_role |
author |
author2 |
Gameiro, Andreia Ferreira, Fernando Correia, Jorge Manuel de Jesus Ferreira, João |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Nascimento, Catarina Gameiro, Andreia Ferreira, Fernando Correia, Jorge Manuel de Jesus Ferreira, João |
dc.subject.por.fl_str_mv |
Feline mammary carcinoma VEGF-A VEGFR-1 VEGFR-2 Non-invasive biomarkers Angiogenesis |
topic |
Feline mammary carcinoma VEGF-A VEGFR-1 VEGFR-2 Non-invasive biomarkers Angiogenesis |
description |
Research Areas: Oncology |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2021-01-01T00:00:00Z 2022-02-13T22:57:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/23477 |
url |
http://hdl.handle.net/10400.5/23477 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nascimento C, Gameiro A, Ferreira J, Correia J, Ferreira F. 2021. Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma. Cancers, 13(1):117. Doi: 10.3390/cancers13010117 10.3390/cancers13010117 2072-6694 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131171045507072 |