Electroanalytical determination of paroxetine in pharmaceuticals

Detalhes bibliográficos
Autor(a) principal: Nouws, Henri P. A.
Data de Publicação: 2006
Outros Autores: Delerue-Matos, Cristina, Barros, Aquiles A., Rodrigues, José A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/2985
Resumo: Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with SWAdSV detection (FIA-SWAdSV) were developed for the determination of paroxetine (PRX). The methods were based on the reduction of PRX at a mercury drop electrode at −1.55V versus Ag/AgCl, in a borate buffer of pH 8.8, and the possibility of accumulating the compound at the electrode surface. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine PRX using FIASWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. Both methods developed were validated and successfully applied to the quantification of PRX in pharmaceutical products.
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spelling Electroanalytical determination of paroxetine in pharmaceuticalsParoxetineSquare-wave adsorptive-stripping voltammetryFlow-injection analysisElectrochemical detectionSSRIElectroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with SWAdSV detection (FIA-SWAdSV) were developed for the determination of paroxetine (PRX). The methods were based on the reduction of PRX at a mercury drop electrode at −1.55V versus Ag/AgCl, in a borate buffer of pH 8.8, and the possibility of accumulating the compound at the electrode surface. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine PRX using FIASWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. Both methods developed were validated and successfully applied to the quantification of PRX in pharmaceutical products.ElsevierRepositório Científico do Instituto Politécnico do PortoNouws, Henri P. A.Delerue-Matos, CristinaBarros, Aquiles A.Rodrigues, José A.2013-11-27T12:14:09Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/2985eng10.1016/j.jpba.2006.04.015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:42:40Zoai:recipp.ipp.pt:10400.22/2985Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:24:00.486028Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Electroanalytical determination of paroxetine in pharmaceuticals
title Electroanalytical determination of paroxetine in pharmaceuticals
spellingShingle Electroanalytical determination of paroxetine in pharmaceuticals
Nouws, Henri P. A.
Paroxetine
Square-wave adsorptive-stripping voltammetry
Flow-injection analysis
Electrochemical detection
SSRI
title_short Electroanalytical determination of paroxetine in pharmaceuticals
title_full Electroanalytical determination of paroxetine in pharmaceuticals
title_fullStr Electroanalytical determination of paroxetine in pharmaceuticals
title_full_unstemmed Electroanalytical determination of paroxetine in pharmaceuticals
title_sort Electroanalytical determination of paroxetine in pharmaceuticals
author Nouws, Henri P. A.
author_facet Nouws, Henri P. A.
Delerue-Matos, Cristina
Barros, Aquiles A.
Rodrigues, José A.
author_role author
author2 Delerue-Matos, Cristina
Barros, Aquiles A.
Rodrigues, José A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Nouws, Henri P. A.
Delerue-Matos, Cristina
Barros, Aquiles A.
Rodrigues, José A.
dc.subject.por.fl_str_mv Paroxetine
Square-wave adsorptive-stripping voltammetry
Flow-injection analysis
Electrochemical detection
SSRI
topic Paroxetine
Square-wave adsorptive-stripping voltammetry
Flow-injection analysis
Electrochemical detection
SSRI
description Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with SWAdSV detection (FIA-SWAdSV) were developed for the determination of paroxetine (PRX). The methods were based on the reduction of PRX at a mercury drop electrode at −1.55V versus Ag/AgCl, in a borate buffer of pH 8.8, and the possibility of accumulating the compound at the electrode surface. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine PRX using FIASWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. Both methods developed were validated and successfully applied to the quantification of PRX in pharmaceutical products.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2013-11-27T12:14:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/2985
url http://hdl.handle.net/10400.22/2985
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jpba.2006.04.015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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