Current trends and challenges of fecal microbiota transplantation—An easy method that works for all?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/22532 |
Resumo: | The gut microbiota refers to bacteria lodges in the gastrointestinal tract (GIT) that interact through various complex mechanisms. The disturbance of this ecosystem has been correlated with several diseases, such as neurologic, respiratory, cardiovascular, and metabolic diseases and cancer. Therefore, the modulation of the gut microbiota has emerged as a potential therapeutic tool; of the various forms of gut microbiota modulation, fecal microbiota transplantation (FMT) is the most approached. This recent technique involves introducing fecal material from a healthy donor into the patient’s gastrointestinal tract, aiming to restore the gut microbiota and lead to the resolution of symptoms. This procedure implies a careful donor choice, fine collection and handling of fecal material, and a balanced preparation of the recipient and consequent administration of the prepared content. Although FMT is considered a biological therapy with promising effects, side effects such as diarrhea and abdominal pain have also been claimed, making this a significant challenge in the application of FMT. Bearing this in mind, the present review aims to summarize the recent advances in understanding FMT mechanisms, their impact across different pathological conditions, and the associated side effects, emphasizing the most recent published data. |
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Current trends and challenges of fecal microbiota transplantation—An easy method that works for all?Fecal microbiota transplantationGut microbiotaNeurological disordersCardiometabolic disordersGastrointestinal disordersCancerThe gut microbiota refers to bacteria lodges in the gastrointestinal tract (GIT) that interact through various complex mechanisms. The disturbance of this ecosystem has been correlated with several diseases, such as neurologic, respiratory, cardiovascular, and metabolic diseases and cancer. Therefore, the modulation of the gut microbiota has emerged as a potential therapeutic tool; of the various forms of gut microbiota modulation, fecal microbiota transplantation (FMT) is the most approached. This recent technique involves introducing fecal material from a healthy donor into the patient’s gastrointestinal tract, aiming to restore the gut microbiota and lead to the resolution of symptoms. This procedure implies a careful donor choice, fine collection and handling of fecal material, and a balanced preparation of the recipient and consequent administration of the prepared content. Although FMT is considered a biological therapy with promising effects, side effects such as diarrhea and abdominal pain have also been claimed, making this a significant challenge in the application of FMT. Bearing this in mind, the present review aims to summarize the recent advances in understanding FMT mechanisms, their impact across different pathological conditions, and the associated side effects, emphasizing the most recent published data.MDPIRepositório Científico do Instituto Politécnico do PortoAlmeida, CátiaOliveira, RitaBaylina, PilarFernandes, RúbenTeixeira, Fábio G.Barata, Pedro2023-03-17T16:59:53Z2022-10-282022-10-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/22532engAlmeida, C.; Oliveira, R.; Baylina, P.; Fernandes, R.; Teixeira, F.G.; Barata, P. Current Trends and Challenges of Fecal Microbiota Transplantation—An Easy Method That Works for All? Biomedicines 2022, 10, 2742. https://doi.org/10.3390/biomedicines1011274210.3390/biomedicines101127422227-9059info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-22T01:47:21Zoai:recipp.ipp.pt:10400.22/22532Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:45:02.505603Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? |
title |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? |
spellingShingle |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? Almeida, Cátia Fecal microbiota transplantation Gut microbiota Neurological disorders Cardiometabolic disorders Gastrointestinal disorders Cancer |
title_short |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? |
title_full |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? |
title_fullStr |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? |
title_full_unstemmed |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? |
title_sort |
Current trends and challenges of fecal microbiota transplantation—An easy method that works for all? |
author |
Almeida, Cátia |
author_facet |
Almeida, Cátia Oliveira, Rita Baylina, Pilar Fernandes, Rúben Teixeira, Fábio G. Barata, Pedro |
author_role |
author |
author2 |
Oliveira, Rita Baylina, Pilar Fernandes, Rúben Teixeira, Fábio G. Barata, Pedro |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Almeida, Cátia Oliveira, Rita Baylina, Pilar Fernandes, Rúben Teixeira, Fábio G. Barata, Pedro |
dc.subject.por.fl_str_mv |
Fecal microbiota transplantation Gut microbiota Neurological disorders Cardiometabolic disorders Gastrointestinal disorders Cancer |
topic |
Fecal microbiota transplantation Gut microbiota Neurological disorders Cardiometabolic disorders Gastrointestinal disorders Cancer |
description |
The gut microbiota refers to bacteria lodges in the gastrointestinal tract (GIT) that interact through various complex mechanisms. The disturbance of this ecosystem has been correlated with several diseases, such as neurologic, respiratory, cardiovascular, and metabolic diseases and cancer. Therefore, the modulation of the gut microbiota has emerged as a potential therapeutic tool; of the various forms of gut microbiota modulation, fecal microbiota transplantation (FMT) is the most approached. This recent technique involves introducing fecal material from a healthy donor into the patient’s gastrointestinal tract, aiming to restore the gut microbiota and lead to the resolution of symptoms. This procedure implies a careful donor choice, fine collection and handling of fecal material, and a balanced preparation of the recipient and consequent administration of the prepared content. Although FMT is considered a biological therapy with promising effects, side effects such as diarrhea and abdominal pain have also been claimed, making this a significant challenge in the application of FMT. Bearing this in mind, the present review aims to summarize the recent advances in understanding FMT mechanisms, their impact across different pathological conditions, and the associated side effects, emphasizing the most recent published data. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-28 2022-10-28T00:00:00Z 2023-03-17T16:59:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/22532 |
url |
http://hdl.handle.net/10400.22/22532 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Almeida, C.; Oliveira, R.; Baylina, P.; Fernandes, R.; Teixeira, F.G.; Barata, P. Current Trends and Challenges of Fecal Microbiota Transplantation—An Easy Method That Works for All? Biomedicines 2022, 10, 2742. https://doi.org/10.3390/biomedicines10112742 10.3390/biomedicines10112742 2227-9059 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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