The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

Detalhes bibliográficos
Autor(a) principal: Castanho, TC
Data de Publicação: 2014
Outros Autores: Moreira, PS, Portugal-Nunes, C, Novais, A, Costa, PS, Palha, JA, Sousa, N, Santos, NC
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/1023
Resumo: Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.
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spelling The role of sex and sex-related hormones in cognition, mood and well-being in older men and womenCogniçãoHormonas Esteróides GonadaisGonadotropinas HipofisáriasAlterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.Repositório Científico do Hospital de BragaCastanho, TCMoreira, PSPortugal-Nunes, CNovais, ACosta, PSPalha, JASousa, NSantos, NC2016-05-04T12:57:48Z2014-12-01T00:00:00Z2014-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1023engBiol Psychol. 2014 Dec;103:158-66.10.1016/j.biopsycho.2014.08.015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:49Zoai:repositorio.hospitaldebraga.pt:10400.23/1023Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:35.859456Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
spellingShingle The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
Castanho, TC
Cognição
Hormonas Esteróides Gonadais
Gonadotropinas Hipofisárias
title_short The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_full The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_fullStr The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_full_unstemmed The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_sort The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
author Castanho, TC
author_facet Castanho, TC
Moreira, PS
Portugal-Nunes, C
Novais, A
Costa, PS
Palha, JA
Sousa, N
Santos, NC
author_role author
author2 Moreira, PS
Portugal-Nunes, C
Novais, A
Costa, PS
Palha, JA
Sousa, N
Santos, NC
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Castanho, TC
Moreira, PS
Portugal-Nunes, C
Novais, A
Costa, PS
Palha, JA
Sousa, N
Santos, NC
dc.subject.por.fl_str_mv Cognição
Hormonas Esteróides Gonadais
Gonadotropinas Hipofisárias
topic Cognição
Hormonas Esteróides Gonadais
Gonadotropinas Hipofisárias
description Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01T00:00:00Z
2014-12-01T00:00:00Z
2016-05-04T12:57:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.23/1023
url http://hdl.handle.net/10400.23/1023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biol Psychol. 2014 Dec;103:158-66.
10.1016/j.biopsycho.2014.08.015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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