The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

Detalhes bibliográficos
Autor(a) principal: Castanho, Teresa C.
Data de Publicação: 2014
Outros Autores: Moreira, Pedro Miguel Silva, Nunes, Carlos Portugal, Novais, Ashley Cruz, Costa, Patrício Soares, Palha, Joana Almeida, Sousa, Nuno, Santos, Nadine Correia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/33255
Resumo: Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.
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spelling The role of sex and sex-related hormones in cognition, mood and well-being in older men and womenExecutive functionMemoryQuality of lifeSleepNutritionSocial SciencesScience & TechnologyAlterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.The work was funded by the European Commission (FP7): "SwitchBox" project (Contract HEALTH-F2-2010-259772) and co-financed by the Portuguese North Regional Operational Program (ON.2-O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). NCS is supported by a "SwitchBox" project post-doctoral fellowship, TCC by a Fundacao para a Ciencia e Tecnologia (FCT, Portugal) doctoral fellowship (BD SFRH/BD/90078/2012), PSM and CPN by a "MyHealth" (Contract DoIT-13853) doctoral and research fellowship, respectively.Elsevier Science BVUniversidade do MinhoCastanho, Teresa C.Moreira, Pedro Miguel SilvaNunes, Carlos PortugalNovais, Ashley CruzCosta, Patrício SoaresPalha, Joana AlmeidaSousa, NunoSantos, Nadine Correia20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/33255eng0301-051110.1016/j.biopsycho.2014.08.01525196100http://www.elsevier.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:28Zoai:repositorium.sdum.uminho.pt:1822/33255Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:51:23.322893Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
spellingShingle The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
Castanho, Teresa C.
Executive function
Memory
Quality of life
Sleep
Nutrition
Social Sciences
Science & Technology
title_short The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_full The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_fullStr The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_full_unstemmed The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
title_sort The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
author Castanho, Teresa C.
author_facet Castanho, Teresa C.
Moreira, Pedro Miguel Silva
Nunes, Carlos Portugal
Novais, Ashley Cruz
Costa, Patrício Soares
Palha, Joana Almeida
Sousa, Nuno
Santos, Nadine Correia
author_role author
author2 Moreira, Pedro Miguel Silva
Nunes, Carlos Portugal
Novais, Ashley Cruz
Costa, Patrício Soares
Palha, Joana Almeida
Sousa, Nuno
Santos, Nadine Correia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Castanho, Teresa C.
Moreira, Pedro Miguel Silva
Nunes, Carlos Portugal
Novais, Ashley Cruz
Costa, Patrício Soares
Palha, Joana Almeida
Sousa, Nuno
Santos, Nadine Correia
dc.subject.por.fl_str_mv Executive function
Memory
Quality of life
Sleep
Nutrition
Social Sciences
Science & Technology
topic Executive function
Memory
Quality of life
Sleep
Nutrition
Social Sciences
Science & Technology
description Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/33255
url http://hdl.handle.net/1822/33255
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0301-0511
10.1016/j.biopsycho.2014.08.015
25196100
http://www.elsevier.com/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science BV
publisher.none.fl_str_mv Elsevier Science BV
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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