Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria

Detalhes bibliográficos
Autor(a) principal: Araújo, Ana Rita Rodrigues
Data de Publicação: 2021
Outros Autores: Araújo, Ana C., Reis, R. L., Pires, R. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/70345
Resumo: "Published online 17 February 2021"
id RCAP_1588606bc3dab9ef68a37f57f25e1e33
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/70345
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteriaCorkVescalaginCastalaginMethicillin-resistant Staphylococcus epidermidisStaphylococcus aureusMethicillin-resistant Staphylococcus aureusPseudomonas aeruginosaScience & Technology"Published online 17 February 2021"Polyphenols have been extensively exploited in the biomedical field because of their wide range of bioactive properties and historical use as traditional medicines. They typically present antioxidant, antimicrobial, antiamyloidogenic, and/or antitumor activities. In particular, cork water extracts and their components, have been previously reported to present antioxidant and antiamyloidogenic properties. On the basis of this knowledge, we tested cork water extract (CWE), cork water enriched extract (CWE-E), vescalagin/castalagin (two of the main polyphenols present in CWE and CWE-E) for their antibacterial activity against four bacterial strains, namely, methicillin-resistant Staphylococcus epidermidis (MRSE), Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa (PA). Vescalagin and castalagin presented bactericidal activity against all the tested bacterial strains, in particular toward the methicillin-resistant ones, i.e., MRSA and MRSE, as well as the ability to inhibit the formation of biofilms and to disrupt preformed ones. Moreover, vescalagin/castalagin seem to modulate the normal assembly of the peptidoglycans at the bacteria surface, promoting the disruption of their cell wall, leading to bacterial cell death. We also demonstrate that vescalagin/castalagin can be loaded into alginate hydrogels to generate antibacterial biomaterials that are not toxic to eukaryotic cells.We acknowledge the financial support from the EC (FORECAST 668983 and MEPHOS 872648). A.R.A. acknowledges the “Programa Operacional Regional do Norte”, “Fundo Social Europeu”, and Norte2020 TERM&SC, for her PhD grant (NORTE-08-5369-FSE-000044).ACS PublicationsUniversidade do MinhoAraújo, Ana Rita RodriguesAraújo, Ana C.Reis, R. L.Pires, R. A.2021-022021-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/70345engAraújo A. R., Araújo A. C., Reis R. L., Pires R. A. Vescalagin and Castalagin Present Bactericidal Activity toward Methicillin-Resistant Bacteria, ACS Biomaterials Science & Engineering, doi:10.1021/acsbiomaterials.0c01698, 20212373-98782373-987810.1021/acsbiomaterials.0c0169833596039https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.0c01698info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:58Zoai:repositorium.sdum.uminho.pt:1822/70345Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:51:00.620314Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
title Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
spellingShingle Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
Araújo, Ana Rita Rodrigues
Cork
Vescalagin
Castalagin
Methicillin-resistant Staphylococcus epidermidis
Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Pseudomonas aeruginosa
Science & Technology
title_short Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
title_full Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
title_fullStr Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
title_full_unstemmed Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
title_sort Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria
author Araújo, Ana Rita Rodrigues
author_facet Araújo, Ana Rita Rodrigues
Araújo, Ana C.
Reis, R. L.
Pires, R. A.
author_role author
author2 Araújo, Ana C.
Reis, R. L.
Pires, R. A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Araújo, Ana Rita Rodrigues
Araújo, Ana C.
Reis, R. L.
Pires, R. A.
dc.subject.por.fl_str_mv Cork
Vescalagin
Castalagin
Methicillin-resistant Staphylococcus epidermidis
Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Pseudomonas aeruginosa
Science & Technology
topic Cork
Vescalagin
Castalagin
Methicillin-resistant Staphylococcus epidermidis
Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Pseudomonas aeruginosa
Science & Technology
description "Published online 17 February 2021"
publishDate 2021
dc.date.none.fl_str_mv 2021-02
2021-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/70345
url http://hdl.handle.net/1822/70345
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Araújo A. R., Araújo A. C., Reis R. L., Pires R. A. Vescalagin and Castalagin Present Bactericidal Activity toward Methicillin-Resistant Bacteria, ACS Biomaterials Science & Engineering, doi:10.1021/acsbiomaterials.0c01698, 2021
2373-9878
2373-9878
10.1021/acsbiomaterials.0c01698
33596039
https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.0c01698
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133096308637696

Registros relacionados