Gut disruption in HIV-2 infection despite reduced viremia

Detalhes bibliográficos
Autor(a) principal: Fernandes, S. M.
Data de Publicação: 2014
Outros Autores: Pires, A. R., Ferreira, C., Tendeiro, R., Correia, L., Paulo, S. E., Victorino, R. M., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/15876
Resumo: Copyright © Lippincott Williams & Wilkins.
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spelling Gut disruption in HIV-2 infection despite reduced viremiaCopyright © Lippincott Williams & Wilkins.HIV-2 infection is highly prevalent inWest Africa and has been increasingly observed in non-African countries, mostly associated with migratory populations [1]. It has a much more benign course and lower viremia than HIV-1 [2], though with similar clinical spectra. Half of the HIV-2 infected patients with less than 200 CD4+ T-cells/ml exhibit undetectable viremia, despite harbouring numbers of infected cells comparable to their HIV-1 counterparts [3]. Moreover, CD4+ T-cell loss occurs in direct association with progressive immune activation in both infections, though the depletion rate is much slower in HIV-2 [2,4]. HIV-1 disease progression has been linked to disruption of gut-associated lymphoid tissue (GALT)and increased levels of microbial translocation, leading to systemic immune activation. There are currently no data on the impact of HIV-2 on GALT. Here, we provide evidence of HIV-2 replication in the gut despite the low viremia, which was associated with major mucosal disruption and CD4+ T-cell depletion that recovered upon antiretroviral treatment (ART).Thiswork was supported by the Fundação para a Ciência e Tecnologia (FCT), and the Programa Operacional Ciência e Inovação 2010 (PIC/IC/82712/2007 to A.E.S.). S.M.F., A.R.P. and R.T. received FCT scholarships.Lippincott, Williams & WilkinsRepositório da Universidade de LisboaFernandes, S. M.Pires, A. R.Ferreira, C.Tendeiro, R.Correia, L.Paulo, S. E.Victorino, R. M.Sousa, A. E.2015-02-03T16:28:19Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/15876engAIDS 2014, Vol 28 No 2, p. 290-2920269-9370http://dx.doi.org/10.1097/QAD.0000000000000114metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:02:47Zoai:repositorio.ul.pt:10451/15876Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:10.643381Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gut disruption in HIV-2 infection despite reduced viremia
title Gut disruption in HIV-2 infection despite reduced viremia
spellingShingle Gut disruption in HIV-2 infection despite reduced viremia
Fernandes, S. M.
title_short Gut disruption in HIV-2 infection despite reduced viremia
title_full Gut disruption in HIV-2 infection despite reduced viremia
title_fullStr Gut disruption in HIV-2 infection despite reduced viremia
title_full_unstemmed Gut disruption in HIV-2 infection despite reduced viremia
title_sort Gut disruption in HIV-2 infection despite reduced viremia
author Fernandes, S. M.
author_facet Fernandes, S. M.
Pires, A. R.
Ferreira, C.
Tendeiro, R.
Correia, L.
Paulo, S. E.
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Pires, A. R.
Ferreira, C.
Tendeiro, R.
Correia, L.
Paulo, S. E.
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fernandes, S. M.
Pires, A. R.
Ferreira, C.
Tendeiro, R.
Correia, L.
Paulo, S. E.
Victorino, R. M.
Sousa, A. E.
description Copyright © Lippincott Williams & Wilkins.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2015-02-03T16:28:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/15876
url http://hdl.handle.net/10451/15876
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv AIDS 2014, Vol 28 No 2, p. 290-292
0269-9370
http://dx.doi.org/10.1097/QAD.0000000000000114
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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