HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/8501 https://doi.org/10.1007/s10038-007-0201-y |
Resumo: | Abstract The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single nucleotide polymorphisms (SNPs) were studied in 100 RA trio families, and 100 other families were used for replication. Genetic analyses were performed by comparing allelic frequencies, by applying the transmission disequilibrium test, and by assessing the genotype relative risk. We observed a significant RA association for the C/C genotype of rs2340690 in the first sample. However, this association was not confirmed when the second sample was added. The two other SNPs and the haplotype analysis did not give any significant results. We conclude that HSPD1 is not a major RA susceptibility gene in the French Caucasian population. |
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HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian populationAbstract The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single nucleotide polymorphisms (SNPs) were studied in 100 RA trio families, and 100 other families were used for replication. Genetic analyses were performed by comparing allelic frequencies, by applying the transmission disequilibrium test, and by assessing the genotype relative risk. We observed a significant RA association for the C/C genotype of rs2340690 in the first sample. However, this association was not confirmed when the second sample was added. The two other SNPs and the haplotype analysis did not give any significant results. We conclude that HSPD1 is not a major RA susceptibility gene in the French Caucasian population.2007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8501http://hdl.handle.net/10316/8501https://doi.org/10.1007/s10038-007-0201-yengJournal of Human Genetics. 52:12 (2007) 1036-1039Jacq, LaurentTeixeira, VitorGarnier, SophieMichou, LaëtitiaDieudé, PhilippeRocha, DominiquePierlot, CélineLemaire, IsabelleQuillet, PatrickHilliquin, PascalMbarek, HamdiPetit-Teixeira, ElisabethCornélis, Françoisinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T02:22:30Zoai:estudogeral.uc.pt:10316/8501Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:33.168655Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population |
title |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population |
spellingShingle |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population Jacq, Laurent |
title_short |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population |
title_full |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population |
title_fullStr |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population |
title_full_unstemmed |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population |
title_sort |
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population |
author |
Jacq, Laurent |
author_facet |
Jacq, Laurent Teixeira, Vitor Garnier, Sophie Michou, Laëtitia Dieudé, Philippe Rocha, Dominique Pierlot, Céline Lemaire, Isabelle Quillet, Patrick Hilliquin, Pascal Mbarek, Hamdi Petit-Teixeira, Elisabeth Cornélis, François |
author_role |
author |
author2 |
Teixeira, Vitor Garnier, Sophie Michou, Laëtitia Dieudé, Philippe Rocha, Dominique Pierlot, Céline Lemaire, Isabelle Quillet, Patrick Hilliquin, Pascal Mbarek, Hamdi Petit-Teixeira, Elisabeth Cornélis, François |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Jacq, Laurent Teixeira, Vitor Garnier, Sophie Michou, Laëtitia Dieudé, Philippe Rocha, Dominique Pierlot, Céline Lemaire, Isabelle Quillet, Patrick Hilliquin, Pascal Mbarek, Hamdi Petit-Teixeira, Elisabeth Cornélis, François |
description |
Abstract The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single nucleotide polymorphisms (SNPs) were studied in 100 RA trio families, and 100 other families were used for replication. Genetic analyses were performed by comparing allelic frequencies, by applying the transmission disequilibrium test, and by assessing the genotype relative risk. We observed a significant RA association for the C/C genotype of rs2340690 in the first sample. However, this association was not confirmed when the second sample was added. The two other SNPs and the haplotype analysis did not give any significant results. We conclude that HSPD1 is not a major RA susceptibility gene in the French Caucasian population. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/8501 http://hdl.handle.net/10316/8501 https://doi.org/10.1007/s10038-007-0201-y |
url |
http://hdl.handle.net/10316/8501 https://doi.org/10.1007/s10038-007-0201-y |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Human Genetics. 52:12 (2007) 1036-1039 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133707747983360 |