No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients

Detalhes bibliográficos
Autor(a) principal: Melo Beirão, J.
Data de Publicação: 2012
Outros Autores: Matos, E., Beirão, I., Costa, P., Torres, P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/952
Resumo: In many transplantation centers domino liver transplantation is an established procedure, increasing the number of available liver grafts. Increasingly, grafts from familial amyloidotic polyneuropathy (FAP) patients are used. Ocular involvement is a well known manifestation of FAP, and can be vision-threatening. The aim of this study was to evaluate the risk of development of familial amyloidotic polyneuropathy ocular manifestations in domino liver recipients. Forty-four cirrhotic patients submitted to liver transplantation were studied, with an average of 6 years of follow up after the procedure. Twenty two patients had received a liver from a FAP donor (Group 1) and 22 had received a liver from a non-FAP cadaveric donor (Group 2). Both groups were similar for mean age and gender. Routine ophthalmological examinations with particular attention to amyloid deposition in the anterior segment and vitreous, peripheral retina state, lacrimal functions tests (Schirmer and tear break-up time) and pupillometry (dynamic and static) were performed. No statistically significant differences were observed in all studied ophthalmic parameters between the two groups. No FAP related ophthalmic manifestations were detected after 6 years of domino liver transplantation, but further prospective regular ophthalmological examinations are necessary to detect the eventual development of late ocular manifestations.
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spelling No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipientsFamilial Amyloidotic PolyneuropathyTransplantationLiverDominoDoenças GenéticasIn many transplantation centers domino liver transplantation is an established procedure, increasing the number of available liver grafts. Increasingly, grafts from familial amyloidotic polyneuropathy (FAP) patients are used. Ocular involvement is a well known manifestation of FAP, and can be vision-threatening. The aim of this study was to evaluate the risk of development of familial amyloidotic polyneuropathy ocular manifestations in domino liver recipients. Forty-four cirrhotic patients submitted to liver transplantation were studied, with an average of 6 years of follow up after the procedure. Twenty two patients had received a liver from a FAP donor (Group 1) and 22 had received a liver from a non-FAP cadaveric donor (Group 2). Both groups were similar for mean age and gender. Routine ophthalmological examinations with particular attention to amyloid deposition in the anterior segment and vitreous, peripheral retina state, lacrimal functions tests (Schirmer and tear break-up time) and pupillometry (dynamic and static) were performed. No statistically significant differences were observed in all studied ophthalmic parameters between the two groups. No FAP related ophthalmic manifestations were detected after 6 years of domino liver transplantation, but further prospective regular ophthalmological examinations are necessary to detect the eventual development of late ocular manifestations.Springer VerlagRepositório Científico do Instituto Nacional de SaúdeMelo Beirão, J.Matos, E.Beirão, I.Costa, P.Torres, P.2012-07-13T15:08:03Z2012-062012-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/952engTranspl Int. 2012 Jun;25(6):646-51. Epub 2012 Mar 220934-0874metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:38:28Zoai:repositorio.insa.pt:10400.18/952Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:36:08.137879Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
title No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
spellingShingle No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
Melo Beirão, J.
Familial Amyloidotic Polyneuropathy
Transplantation
Liver
Domino
Doenças Genéticas
title_short No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
title_full No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
title_fullStr No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
title_full_unstemmed No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
title_sort No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
author Melo Beirão, J.
author_facet Melo Beirão, J.
Matos, E.
Beirão, I.
Costa, P.
Torres, P.
author_role author
author2 Matos, E.
Beirão, I.
Costa, P.
Torres, P.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Melo Beirão, J.
Matos, E.
Beirão, I.
Costa, P.
Torres, P.
dc.subject.por.fl_str_mv Familial Amyloidotic Polyneuropathy
Transplantation
Liver
Domino
Doenças Genéticas
topic Familial Amyloidotic Polyneuropathy
Transplantation
Liver
Domino
Doenças Genéticas
description In many transplantation centers domino liver transplantation is an established procedure, increasing the number of available liver grafts. Increasingly, grafts from familial amyloidotic polyneuropathy (FAP) patients are used. Ocular involvement is a well known manifestation of FAP, and can be vision-threatening. The aim of this study was to evaluate the risk of development of familial amyloidotic polyneuropathy ocular manifestations in domino liver recipients. Forty-four cirrhotic patients submitted to liver transplantation were studied, with an average of 6 years of follow up after the procedure. Twenty two patients had received a liver from a FAP donor (Group 1) and 22 had received a liver from a non-FAP cadaveric donor (Group 2). Both groups were similar for mean age and gender. Routine ophthalmological examinations with particular attention to amyloid deposition in the anterior segment and vitreous, peripheral retina state, lacrimal functions tests (Schirmer and tear break-up time) and pupillometry (dynamic and static) were performed. No statistically significant differences were observed in all studied ophthalmic parameters between the two groups. No FAP related ophthalmic manifestations were detected after 6 years of domino liver transplantation, but further prospective regular ophthalmological examinations are necessary to detect the eventual development of late ocular manifestations.
publishDate 2012
dc.date.none.fl_str_mv 2012-07-13T15:08:03Z
2012-06
2012-06-01T00:00:00Z
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dc.relation.none.fl_str_mv Transpl Int. 2012 Jun;25(6):646-51. Epub 2012 Mar 22
0934-0874
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dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
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