Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7

Detalhes bibliográficos
Autor(a) principal: Longatto Filho, Adhemar
Data de Publicação: 2014
Outros Autores: Porto, Claudia Regina Cinti, Kleine, João Paulo Ferreira de Oliveira, Silva, Ismael Dale Cotrim Guerreiro da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/32834
Resumo: The present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of São Paulo. Interleukin-6 polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and analyzed in 3% agarose gel. RESULTS: No significant associations between the frequency of the polymorphism of IL6 in patients expressing E6 and E7 with HPV-positive and -negative reactions were found. There was no statistically significant difference between the case and control group for genotype distribution (p=0.280). CONCLUSION: Genotypic analysis showed a striking similarity of IL6 polymorphisms in both cases and controls. The allelic distribution in cases and controls for G and C of IL6 were very similar (p=0.186), which could point to similar IL6 functionality for both groups.
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spelling Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7Gene polymorphismIL6HPVE6/E7Science & TechnologyThe present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of São Paulo. Interleukin-6 polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and analyzed in 3% agarose gel. RESULTS: No significant associations between the frequency of the polymorphism of IL6 in patients expressing E6 and E7 with HPV-positive and -negative reactions were found. There was no statistically significant difference between the case and control group for genotype distribution (p=0.280). CONCLUSION: Genotypic analysis showed a striking similarity of IL6 polymorphisms in both cases and controls. The allelic distribution in cases and controls for G and C of IL6 were very similar (p=0.186), which could point to similar IL6 functionality for both groups.International Institute of Anticancer Research (IIAR)Universidade do MinhoLongatto Filho, AdhemarPorto, Claudia Regina CintiKleine, João Paulo Ferreira de OliveiraSilva, Ismael Dale Cotrim Guerreiro da20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32834eng0250-700524982360http://ar.iiarjournals.org/content/34/7/3501.abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T05:19:00Zoai:repositorium.sdum.uminho.pt:1822/32834Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T05:19Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
title Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
spellingShingle Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
Longatto Filho, Adhemar
Gene polymorphism
IL6
HPV
E6/E7
Science & Technology
title_short Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
title_full Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
title_fullStr Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
title_full_unstemmed Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
title_sort Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7
author Longatto Filho, Adhemar
author_facet Longatto Filho, Adhemar
Porto, Claudia Regina Cinti
Kleine, João Paulo Ferreira de Oliveira
Silva, Ismael Dale Cotrim Guerreiro da
author_role author
author2 Porto, Claudia Regina Cinti
Kleine, João Paulo Ferreira de Oliveira
Silva, Ismael Dale Cotrim Guerreiro da
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Longatto Filho, Adhemar
Porto, Claudia Regina Cinti
Kleine, João Paulo Ferreira de Oliveira
Silva, Ismael Dale Cotrim Guerreiro da
dc.subject.por.fl_str_mv Gene polymorphism
IL6
HPV
E6/E7
Science & Technology
topic Gene polymorphism
IL6
HPV
E6/E7
Science & Technology
description The present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of São Paulo. Interleukin-6 polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and analyzed in 3% agarose gel. RESULTS: No significant associations between the frequency of the polymorphism of IL6 in patients expressing E6 and E7 with HPV-positive and -negative reactions were found. There was no statistically significant difference between the case and control group for genotype distribution (p=0.280). CONCLUSION: Genotypic analysis showed a striking similarity of IL6 polymorphisms in both cases and controls. The allelic distribution in cases and controls for G and C of IL6 were very similar (p=0.186), which could point to similar IL6 functionality for both groups.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/32834
url http://hdl.handle.net/1822/32834
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0250-7005
24982360
http://ar.iiarjournals.org/content/34/7/3501.abstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Institute of Anticancer Research (IIAR)
publisher.none.fl_str_mv International Institute of Anticancer Research (IIAR)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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