Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina

Detalhes bibliográficos
Autor(a) principal: Kramer, Joshua
Data de Publicação: 2021
Outros Autores: Neves, Joana, Koniikusic, Mia, Jasper, Heinrich, Lamba, Deepak A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50219
Resumo: © 2021 Kramer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina© 2021 Kramer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Retinal homeostasis relies on intricate coordination of cell death and survival in response to stress and damage. Signaling mechanisms that coordinate this process in the adult retina remain poorly understood. Here we identify Decapentaplegic (Dpp) signaling in Drosophila and its mammalian homologue Transforming Growth Factor-beta (TGFβ) superfamily, that includes TGFβ and Bone Morphogenetic Protein (BMP) signaling arms, as central mediators of retinal neuronal death and tissue survival following acute damage. Using a Drosophila model for UV-induced retinal damage, we show that Dpp released from immune cells promotes tissue loss after UV-induced retinal damage. Interestingly, we find a dynamic response of retinal cells to this signal: in an early phase, Dpp-mediated stimulation of Saxophone/Smox signaling promotes apoptosis, while at a later stage, stimulation of the Thickveins/Mad axis promotes tissue repair and survival. This dual role is conserved in the mammalian retina through the TGFβ/BMP signaling, as supplementation of BMP4 or inhibition of TGFβ using small molecules promotes retinal cell survival, while inhibition of BMP negatively affects cell survival after light-induced photoreceptor damage and NMDA induced inner retinal neuronal damage. Our data identify key evolutionarily conserved mechanisms by which retinal homeostasis is maintained.The research presented here is supported by NIH grants (R01 EY025779 and EY032197 to DL; AG057353 and EY018177 to HJ; P30 Vision Core grant to UCSF Dept of Ophthalmology), and the Research to Prevent Blindness (unrestricted grant to UCSF Dept of Ophthalmology).PLOSRepositório da Universidade de LisboaKramer, JoshuaNeves, JoanaKoniikusic, MiaJasper, HeinrichLamba, Deepak A.2021-11-30T13:53:24Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50219engPLoS One. 2021 Oct 26;16(10):e025887210.1371/journal.pone.02588721932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:10Zoai:repositorio.ul.pt:10451/50219Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:37.110331Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
title Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
spellingShingle Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
Kramer, Joshua
title_short Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
title_full Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
title_fullStr Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
title_full_unstemmed Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
title_sort Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina
author Kramer, Joshua
author_facet Kramer, Joshua
Neves, Joana
Koniikusic, Mia
Jasper, Heinrich
Lamba, Deepak A.
author_role author
author2 Neves, Joana
Koniikusic, Mia
Jasper, Heinrich
Lamba, Deepak A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Kramer, Joshua
Neves, Joana
Koniikusic, Mia
Jasper, Heinrich
Lamba, Deepak A.
description © 2021 Kramer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-30T13:53:24Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50219
url http://hdl.handle.net/10451/50219
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS One. 2021 Oct 26;16(10):e0258872
10.1371/journal.pone.0258872
1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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