Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/156142 |
Resumo: | Flores, R., Fradinho, A. C., Pereira, R. S., Mendes, J. M., Seabra, M. C., Tenreiro, S., & Carneiro, Â. (2023). Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression. Translational Vision Science & Technology, 12(7), 1-13. [22]. https://doi.org/10.1167/tvst.12.7.22 --- Supported by iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior. ACF was recipient of individual PhD fellowship funded by FCT (PD/BD/135503/2018). |
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Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progressionintermediate AMDlate AMDprogression biomarkersSD-OCTBiomedical EngineeringOphthalmologyFlores, R., Fradinho, A. C., Pereira, R. S., Mendes, J. M., Seabra, M. C., Tenreiro, S., & Carneiro, Â. (2023). Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression. Translational Vision Science & Technology, 12(7), 1-13. [22]. https://doi.org/10.1167/tvst.12.7.22 --- Supported by iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior. ACF was recipient of individual PhD fellowship funded by FCT (PD/BD/135503/2018).Purpose: Intermediate age-related macular degeneration (iAMD) is a risk factor for progression to advanced stages, but rates of progression vary between individuals. Predicting individual risk is advantageous for programing timely and effective treatment and for patient stratification into future clinical trials. Methods: We conducted a prospective and noninterventional study following patients with iAMD for 24 months. Optical coherence tomography parameters related with drusen, hyper-reflective foci (HRF), presence of incomplete retinal pigment epithelial and outer retinal atrophy (iRORA) and ellipsoid zone (EZ) status were explored at the baseline. Patients were reclassified at the end of the follow-up period and divided according to their progression. A risk prediction model for progression to late AMD was developed. Results: A total of 135 patients were enrolled in the study and 30.4% developed late disease. A multivariate logistic regression model was created using those optical coherence tomography parameters, further optimized by backward feature elimination. Parameters offering the best fit in prediction progression were presence of iRORA, EZ status, drusen area and presence of HRF. iRORA is the feature that provides a higher probability of developing late AMD (odds ratio, 12.91; P = 0.000), followed by EZ disruption status (odds ratio, 3.54; P = 0.0018). The area under the receiver operating characteristic curve calculated for the testing set was 0.77 (95% confidence interval, 0.56–0.98). Conclusions: The combination of iRORA and EZ disruption constitute a high risk of progression to complete RORA within 2 years. Translational Relevance: We propose a practical and useful model to help clinicians in their daily practice in predicting individual progression to advanced AMD.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSInformation Management Research Center (MagIC) - NOVA Information Management SchoolNOVA Information Management School (NOVA IMS)RUNFlores, RitaFradinho, Ana C.Pereira, Rita SerrasMendes, Jorge M.Seabra, Miguel C.Tenreiro, SandraCarneiro, Ângela2023-08-01T22:20:20Z2023-07-252023-07-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/156142eng2164-2591PURE: 67844791https://doi.org/10.1167/tvst.12.7.22info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:38:43Zoai:run.unl.pt:10362/156142Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:20.942948Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression |
title |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression |
spellingShingle |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression Flores, Rita intermediate AMD late AMD progression biomarkers SD-OCT Biomedical Engineering Ophthalmology |
title_short |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression |
title_full |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression |
title_fullStr |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression |
title_full_unstemmed |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression |
title_sort |
Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression |
author |
Flores, Rita |
author_facet |
Flores, Rita Fradinho, Ana C. Pereira, Rita Serras Mendes, Jorge M. Seabra, Miguel C. Tenreiro, Sandra Carneiro, Ângela |
author_role |
author |
author2 |
Fradinho, Ana C. Pereira, Rita Serras Mendes, Jorge M. Seabra, Miguel C. Tenreiro, Sandra Carneiro, Ângela |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) iNOVA4Health - pólo NMS Information Management Research Center (MagIC) - NOVA Information Management School NOVA Information Management School (NOVA IMS) RUN |
dc.contributor.author.fl_str_mv |
Flores, Rita Fradinho, Ana C. Pereira, Rita Serras Mendes, Jorge M. Seabra, Miguel C. Tenreiro, Sandra Carneiro, Ângela |
dc.subject.por.fl_str_mv |
intermediate AMD late AMD progression biomarkers SD-OCT Biomedical Engineering Ophthalmology |
topic |
intermediate AMD late AMD progression biomarkers SD-OCT Biomedical Engineering Ophthalmology |
description |
Flores, R., Fradinho, A. C., Pereira, R. S., Mendes, J. M., Seabra, M. C., Tenreiro, S., & Carneiro, Â. (2023). Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression. Translational Vision Science & Technology, 12(7), 1-13. [22]. https://doi.org/10.1167/tvst.12.7.22 --- Supported by iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior. ACF was recipient of individual PhD fellowship funded by FCT (PD/BD/135503/2018). |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-01T22:20:20Z 2023-07-25 2023-07-25T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/156142 |
url |
http://hdl.handle.net/10362/156142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2164-2591 PURE: 67844791 https://doi.org/10.1167/tvst.12.7.22 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
13 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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