Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/8272 https://doi.org/10.1002/elan.200603602 |
Resumo: | Glivec is a relatively small molecule with activity against the protein tyrosine kinase, a protein expressed by all patients with chronic myelogenous leukemia (CML). Based on its activity on CML, glivec is undergoing extensive evaluation of its activity against other types of tumor. As a result, there is an ongoing need for clarification of glivec pharmacokinetics so that issues such as drug-biomolecular complex interactions can be understood. |
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Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical MetaboliteGlivec is a relatively small molecule with activity against the protein tyrosine kinase, a protein expressed by all patients with chronic myelogenous leukemia (CML). Based on its activity on CML, glivec is undergoing extensive evaluation of its activity against other types of tumor. As a result, there is an ongoing need for clarification of glivec pharmacokinetics so that issues such as drug-biomolecular complex interactions can be understood.2006info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8272http://hdl.handle.net/10316/8272https://doi.org/10.1002/elan.200603602engElectroanalysis. 18:19-20 (2006) 1963-1970Diculescu, Victor ConstantinVivan, MarileneBrett, Ana Maria Oliveirainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T13:16:12Zoai:estudogeral.uc.pt:10316/8272Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:43.052646Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite |
title |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite |
spellingShingle |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite Diculescu, Victor Constantin |
title_short |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite |
title_full |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite |
title_fullStr |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite |
title_full_unstemmed |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite |
title_sort |
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidative Damage by the Glivec Electrochemical Metabolite |
author |
Diculescu, Victor Constantin |
author_facet |
Diculescu, Victor Constantin Vivan, Marilene Brett, Ana Maria Oliveira |
author_role |
author |
author2 |
Vivan, Marilene Brett, Ana Maria Oliveira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Diculescu, Victor Constantin Vivan, Marilene Brett, Ana Maria Oliveira |
description |
Glivec is a relatively small molecule with activity against the protein tyrosine kinase, a protein expressed by all patients with chronic myelogenous leukemia (CML). Based on its activity on CML, glivec is undergoing extensive evaluation of its activity against other types of tumor. As a result, there is an ongoing need for clarification of glivec pharmacokinetics so that issues such as drug-biomolecular complex interactions can be understood. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/8272 http://hdl.handle.net/10316/8272 https://doi.org/10.1002/elan.200603602 |
url |
http://hdl.handle.net/10316/8272 https://doi.org/10.1002/elan.200603602 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Electroanalysis. 18:19-20 (2006) 1963-1970 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133907865567232 |