Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/3835 https://doi.org/10.1016/S0378-5173(99)00375-0 |
Resumo: | Studies of dynamic and equilibrium swelling, structural characterisation and solute transport in swollen poly(2-hydroxyethyl methacrylate) gels (pHEMA) cross-linked with tripropyleneglycol diacrylate (TPGDA) were done for a wide range of TPGDA concentrations. The influence of the pH on these pHEMA properties was evaluated. In swelling studies it was found that in changing the pH from 6.5 to 12.0, a large increase in swelling occurred, from approximately 48 to 55%, for the lowest concentration of TPGDA (1 mol%), and from 40 to 80% for the highest concentration (10mol%). Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC) measurements were made after the equilibrium swelling of the gels at different pH values, to explain these results. The advantage of using these gels as controlled drug delivery systems is illustrated using salicylic acid (SA) as a model drug. The loading and the release of the SA were made at different pH values and the results obtained showed that it is possible to modulate the hydrogel performance by controlling an external factor, the pH at which the drug loading and release were performed. |
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Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH valuesHydroxyethyl methacrylateHydrogelsSwellingSalicylic acidControlled releaseStructural characterisationStudies of dynamic and equilibrium swelling, structural characterisation and solute transport in swollen poly(2-hydroxyethyl methacrylate) gels (pHEMA) cross-linked with tripropyleneglycol diacrylate (TPGDA) were done for a wide range of TPGDA concentrations. The influence of the pH on these pHEMA properties was evaluated. In swelling studies it was found that in changing the pH from 6.5 to 12.0, a large increase in swelling occurred, from approximately 48 to 55%, for the lowest concentration of TPGDA (1 mol%), and from 40 to 80% for the highest concentration (10mol%). Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC) measurements were made after the equilibrium swelling of the gels at different pH values, to explain these results. The advantage of using these gels as controlled drug delivery systems is illustrated using salicylic acid (SA) as a model drug. The loading and the release of the SA were made at different pH values and the results obtained showed that it is possible to modulate the hydrogel performance by controlling an external factor, the pH at which the drug loading and release were performed.http://www.sciencedirect.com/science/article/B6T7W-3YMW350-4/1/bd1b81f7d9f216abf72881a42ad0163e2000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/3835http://hdl.handle.net/10316/3835https://doi.org/10.1016/S0378-5173(99)00375-0engInternational Journal of Pharmaceutics. 194:2 (2000) 169-180Ferreira, L.Vidal, M. M.Gil, M. H.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:59:50Zoai:estudogeral.uc.pt:10316/3835Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:59:16.648471Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values |
title |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values |
spellingShingle |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values Ferreira, L. Hydroxyethyl methacrylate Hydrogels Swelling Salicylic acid Controlled release Structural characterisation |
title_short |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values |
title_full |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values |
title_fullStr |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values |
title_full_unstemmed |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values |
title_sort |
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values |
author |
Ferreira, L. |
author_facet |
Ferreira, L. Vidal, M. M. Gil, M. H. |
author_role |
author |
author2 |
Vidal, M. M. Gil, M. H. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Ferreira, L. Vidal, M. M. Gil, M. H. |
dc.subject.por.fl_str_mv |
Hydroxyethyl methacrylate Hydrogels Swelling Salicylic acid Controlled release Structural characterisation |
topic |
Hydroxyethyl methacrylate Hydrogels Swelling Salicylic acid Controlled release Structural characterisation |
description |
Studies of dynamic and equilibrium swelling, structural characterisation and solute transport in swollen poly(2-hydroxyethyl methacrylate) gels (pHEMA) cross-linked with tripropyleneglycol diacrylate (TPGDA) were done for a wide range of TPGDA concentrations. The influence of the pH on these pHEMA properties was evaluated. In swelling studies it was found that in changing the pH from 6.5 to 12.0, a large increase in swelling occurred, from approximately 48 to 55%, for the lowest concentration of TPGDA (1 mol%), and from 40 to 80% for the highest concentration (10mol%). Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC) measurements were made after the equilibrium swelling of the gels at different pH values, to explain these results. The advantage of using these gels as controlled drug delivery systems is illustrated using salicylic acid (SA) as a model drug. The loading and the release of the SA were made at different pH values and the results obtained showed that it is possible to modulate the hydrogel performance by controlling an external factor, the pH at which the drug loading and release were performed. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/3835 http://hdl.handle.net/10316/3835 https://doi.org/10.1016/S0378-5173(99)00375-0 |
url |
http://hdl.handle.net/10316/3835 https://doi.org/10.1016/S0378-5173(99)00375-0 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Pharmaceutics. 194:2 (2000) 169-180 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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