Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate

Detalhes bibliográficos
Autor(a) principal: Ferreira, L.
Data de Publicação: 2000
Outros Autores: Vidal, M. M., Geraldes, C. F. G. C., Gil, M. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.1016/s0144-8617(97)87382-1
Texto Completo: http://hdl.handle.net/10316/3836
https://doi.org/10.1016/s0144-8617(97)87382-1
Resumo: Sugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hydroxyethyl methacrylate (HEMA) and SucMA in a 70:30 ethylene glycol/water mixed solvent using ammonium persulphate/sodium methabisulphite pair as initiating system. The swelling behaviour of these gels was evaluated as a function of crosslinker content, copolymer composition, pH and ionic strength. In addition, the diffusional behaviour of sodium salycilate (SSA) from these gels and poly(HEMA) gels is also reported.
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spelling Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylateSucroseGlycidyl methacrylateSwellingDrug releaseSugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hydroxyethyl methacrylate (HEMA) and SucMA in a 70:30 ethylene glycol/water mixed solvent using ammonium persulphate/sodium methabisulphite pair as initiating system. The swelling behaviour of these gels was evaluated as a function of crosslinker content, copolymer composition, pH and ionic strength. In addition, the diffusional behaviour of sodium salycilate (SSA) from these gels and poly(HEMA) gels is also reported.http://www.sciencedirect.com/science/article/B6TFD-3XV2JTG-3/1/ad1327d644fe45111347ac202ea96c9b2000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/3836http://hdl.handle.net/10316/3836https://doi.org/10.1016/s0144-8617(97)87382-1engCarbohydrate Polymers. 41:1 (2000) 15-24Ferreira, L.Vidal, M. M.Geraldes, C. F. G. C.Gil, M. H.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-09-01T08:56:56Zoai:estudogeral.uc.pt:10316/3836Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:59:16.695183Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
title Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
spellingShingle Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
Ferreira, L.
Sucrose
Glycidyl methacrylate
Swelling
Drug release
Ferreira, L.
Sucrose
Glycidyl methacrylate
Swelling
Drug release
title_short Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
title_full Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
title_fullStr Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
title_full_unstemmed Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
title_sort Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
author Ferreira, L.
author_facet Ferreira, L.
Ferreira, L.
Vidal, M. M.
Geraldes, C. F. G. C.
Gil, M. H.
Vidal, M. M.
Geraldes, C. F. G. C.
Gil, M. H.
author_role author
author2 Vidal, M. M.
Geraldes, C. F. G. C.
Gil, M. H.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ferreira, L.
Vidal, M. M.
Geraldes, C. F. G. C.
Gil, M. H.
dc.subject.por.fl_str_mv Sucrose
Glycidyl methacrylate
Swelling
Drug release
topic Sucrose
Glycidyl methacrylate
Swelling
Drug release
description Sugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hydroxyethyl methacrylate (HEMA) and SucMA in a 70:30 ethylene glycol/water mixed solvent using ammonium persulphate/sodium methabisulphite pair as initiating system. The swelling behaviour of these gels was evaluated as a function of crosslinker content, copolymer composition, pH and ionic strength. In addition, the diffusional behaviour of sodium salycilate (SSA) from these gels and poly(HEMA) gels is also reported.
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/3836
http://hdl.handle.net/10316/3836
https://doi.org/10.1016/s0144-8617(97)87382-1
url http://hdl.handle.net/10316/3836
https://doi.org/10.1016/s0144-8617(97)87382-1
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carbohydrate Polymers. 41:1 (2000) 15-24
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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dc.identifier.doi.none.fl_str_mv 10.1016/s0144-8617(97)87382-1

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