Targeting the aryl hydrocarbon receptor by gut phenolic metabolites

• Autor(a) principal: Pinto, Catarina J.G.
• Data de Publicação: 2023
• Outros Autores: Ávila-Gálvez, María Ángeles, Lian, Yilong, Moura-Alves, Pedro, Nunes dos Santos, Cláudia
• Tipo de documento: Outros
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/150335
• topic: AHR; Dietary (poly)phenols; Inflammatory bowel disease; Microbiota; Organic Chemistry; Clinical Biochemistry

Funding Information: Several clinical trials support that the specific CD exclusion diet and the UC exclusion diet are well-established procedures to achieve remission in those patients [166]. Besides, carbohydrate diet patterns have been shown to help clinical remission in paediatric patients with CD [167,168]. However, these diets are very restrictive diets depriving people of a large number of foods. The Mediterranean diet has gained popularity to prevent and/or treat IBD due to its potential in decreasing inflammatory markers and mortality in IBD patients [169,170]. Regular consumption of a Mediterranean diet in healthy people decreases the risk of developing IBD associated with specific gut microbiome regulation as well as a reduction in gut inflammatory markers (e.g., calprotectin) [171]. The beneficial effects of long-lasting adherence to the Mediterranean diet have been attributed to specific components like (poly)phenols [172], which are very abundant in this diet and are associated with immunomodulatory properties and a reduced incidence of inflammation.This work was supported by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co-funded by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged (UIDB/04462/2020 and UIDP/04462/2020). Y. Lian and P. Moura-Alves acknowledge the support of the Ludwig Institute for Cancer Research- Core Award, and P. Moura-Alves the H2020-WIDESPREAD-2018-951921- ImmunoHUB. Authors would like to acknowledge FCT for financial support of C. J. G. Pinto (2022.11465. BD). Funding Information: This work was supported by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229 . iNOVA4Health Research Unit ( LISBOA-01-0145-FEDER-007344 ), which is co-funded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior , through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged ( UIDB/04462/2020 and UIDP/04462/2020 ). Y. Lian and P. Moura-Alves acknowledge the support of the Ludwig Institute for Cancer Research- Core Award , and P. Moura-Alves the H2020-WIDESPREAD-2018-951921- ImmunoHUB . Authors would like to acknowledge FCT for financial support of C. J. G. Pinto ( 2022.11465 . BD). Publisher Copyright: © 2023 The Authors