Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/158476 |
Resumo: | A retrospective study was conducted to analyze prescription pattern of clozapine in dual diagnosis inpatients' and to find out if there was any association between clozapine prescription and acute relapses either from psychiatric symptoms or from substance use disorder. All patients admitted at Lisbon's Psychiatric Hospital Center during a 4 months' period for psychiatric inpatient treatment with a dual diagnosis at discharge were selected and their clinical files were screened. From 536 patients, 17,5% had a dual diagnosis at discharge. Most frequent psychiatric diagnosis associated with substance use disorder was schizophrenia (50%), followed by major depression disorder (17%) and bipolar disorder (10,6%). Most frequent substance of abuse was alcohol, followed by cannabinoids, nicotine, cocaine, and opiates. At least one antipsychotic drug was prescribed to 85,1% patients, and clozapine was prescribed to 22,3%. There was a statistically significant association between clozapine prescription and prevention of acute relapses of psychiatric symptoms in dual diagnosis patients. Although there was no significant association between prescription of clozapine versus other antipsychotic drugs in the prevention of relapses of substance use, there was a larger than expected number of patients in clozapine that didn't have a relapse of substance use. |
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Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorderA retrospective inpatient analysisClozapineDual diagnosisRelapsesSchizophreniaSubstance use disorderTreatmentPsychiatry and Mental healthBiological PsychiatrySDG 3 - Good Health and Well-beingA retrospective study was conducted to analyze prescription pattern of clozapine in dual diagnosis inpatients' and to find out if there was any association between clozapine prescription and acute relapses either from psychiatric symptoms or from substance use disorder. All patients admitted at Lisbon's Psychiatric Hospital Center during a 4 months' period for psychiatric inpatient treatment with a dual diagnosis at discharge were selected and their clinical files were screened. From 536 patients, 17,5% had a dual diagnosis at discharge. Most frequent psychiatric diagnosis associated with substance use disorder was schizophrenia (50%), followed by major depression disorder (17%) and bipolar disorder (10,6%). Most frequent substance of abuse was alcohol, followed by cannabinoids, nicotine, cocaine, and opiates. At least one antipsychotic drug was prescribed to 85,1% patients, and clozapine was prescribed to 22,3%. There was a statistically significant association between clozapine prescription and prevention of acute relapses of psychiatric symptoms in dual diagnosis patients. Although there was no significant association between prescription of clozapine versus other antipsychotic drugs in the prevention of relapses of substance use, there was a larger than expected number of patients in clozapine that didn't have a relapse of substance use.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNTeixeira, JoanaAlexandre, SaraCunha, CarolinaRaposo, FilipeCosta, José Pedro2023-09-29T22:21:36Z2022-092022-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158476eng2772-5987PURE: 72195406https://doi.org/10.1016/j.psycom.2022.100056info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:53Zoai:run.unl.pt:10362/158476Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:09.554281Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder A retrospective inpatient analysis |
title |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder |
spellingShingle |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder Teixeira, Joana Clozapine Dual diagnosis Relapses Schizophrenia Substance use disorder Treatment Psychiatry and Mental health Biological Psychiatry SDG 3 - Good Health and Well-being |
title_short |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder |
title_full |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder |
title_fullStr |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder |
title_full_unstemmed |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder |
title_sort |
Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder |
author |
Teixeira, Joana |
author_facet |
Teixeira, Joana Alexandre, Sara Cunha, Carolina Raposo, Filipe Costa, José Pedro |
author_role |
author |
author2 |
Alexandre, Sara Cunha, Carolina Raposo, Filipe Costa, José Pedro |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Teixeira, Joana Alexandre, Sara Cunha, Carolina Raposo, Filipe Costa, José Pedro |
dc.subject.por.fl_str_mv |
Clozapine Dual diagnosis Relapses Schizophrenia Substance use disorder Treatment Psychiatry and Mental health Biological Psychiatry SDG 3 - Good Health and Well-being |
topic |
Clozapine Dual diagnosis Relapses Schizophrenia Substance use disorder Treatment Psychiatry and Mental health Biological Psychiatry SDG 3 - Good Health and Well-being |
description |
A retrospective study was conducted to analyze prescription pattern of clozapine in dual diagnosis inpatients' and to find out if there was any association between clozapine prescription and acute relapses either from psychiatric symptoms or from substance use disorder. All patients admitted at Lisbon's Psychiatric Hospital Center during a 4 months' period for psychiatric inpatient treatment with a dual diagnosis at discharge were selected and their clinical files were screened. From 536 patients, 17,5% had a dual diagnosis at discharge. Most frequent psychiatric diagnosis associated with substance use disorder was schizophrenia (50%), followed by major depression disorder (17%) and bipolar disorder (10,6%). Most frequent substance of abuse was alcohol, followed by cannabinoids, nicotine, cocaine, and opiates. At least one antipsychotic drug was prescribed to 85,1% patients, and clozapine was prescribed to 22,3%. There was a statistically significant association between clozapine prescription and prevention of acute relapses of psychiatric symptoms in dual diagnosis patients. Although there was no significant association between prescription of clozapine versus other antipsychotic drugs in the prevention of relapses of substance use, there was a larger than expected number of patients in clozapine that didn't have a relapse of substance use. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09 2022-09-01T00:00:00Z 2023-09-29T22:21:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158476 |
url |
http://hdl.handle.net/10362/158476 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2772-5987 PURE: 72195406 https://doi.org/10.1016/j.psycom.2022.100056 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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