Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/705 |
Resumo: | This retrospective study was designed to evaluate the outcome of pregnancies in women diagnosed with systemic lupus erythematosus (SLE) followed in a tertiary fetal–maternal center. Data were collected from clinical charts between January 1993 and December 2007, with a total of 136 pregnancies (107 patients). Mean maternal age was 29 years, with the vast majority of patients being Caucasian. Most patients were in remission 6 months prior to pregnancy (93%) and the most frequently affected organs were the skin and joints. Renal lupus accounted for 14% of all cases. Twenty-nine percent of patients were positive for at least one antiphospholid antibody (aPL) and nearly 50% had positive SSa/SSb antibodies. All patients with positive aPL received low-dosage aspirin and low molecular- weight heparin (LMWH). There were no pregnancy complications in more than 50% of cases and hypertensive disease and intrauterine growth restriction were the most common adverse events. There were 125 live births, one neonatal death, eight miscarriages, and three medical terminations of pregnancy. Preterm delivery occurred in 25% of pregnancies. Our results are probably the conjoined result of a multidisciplinary approach together with a systematic management of SLE pregnancies, with most patients keeping their prior SLE medication combined with low-dosage aspirin and LMWH in the presence of aPL. |
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Lupus and Pregnancy. 15 Years of Experience in a Tertiary CenterLupus Erythematosus, Systemic/complicationsLupus Erythematosus, Systemic/physiopathologyPregnancy Complications/immunologyPregnancy Complications/physiopathologyPregnancy OutcomeMAC MED MAFMAC MEDPregnancyRetrospective StudiesThis retrospective study was designed to evaluate the outcome of pregnancies in women diagnosed with systemic lupus erythematosus (SLE) followed in a tertiary fetal–maternal center. Data were collected from clinical charts between January 1993 and December 2007, with a total of 136 pregnancies (107 patients). Mean maternal age was 29 years, with the vast majority of patients being Caucasian. Most patients were in remission 6 months prior to pregnancy (93%) and the most frequently affected organs were the skin and joints. Renal lupus accounted for 14% of all cases. Twenty-nine percent of patients were positive for at least one antiphospholid antibody (aPL) and nearly 50% had positive SSa/SSb antibodies. All patients with positive aPL received low-dosage aspirin and low molecular- weight heparin (LMWH). There were no pregnancy complications in more than 50% of cases and hypertensive disease and intrauterine growth restriction were the most common adverse events. There were 125 live births, one neonatal death, eight miscarriages, and three medical terminations of pregnancy. Preterm delivery occurred in 25% of pregnancies. Our results are probably the conjoined result of a multidisciplinary approach together with a systematic management of SLE pregnancies, with most patients keeping their prior SLE medication combined with low-dosage aspirin and LMWH in the presence of aPL.SpringerRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEAmbrósio, PLermann, RCordeiro, ABorges, ANogueira, ISerrano, F2012-10-30T15:26:19Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/705engClin Rev Allergy Immunol. 2010 Apr;38(2-3):77-81info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:27:45Zoai:repositorio.chlc.min-saude.pt:10400.17/705Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:18:25.767451Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center |
title |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center |
spellingShingle |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center Ambrósio, P Lupus Erythematosus, Systemic/complications Lupus Erythematosus, Systemic/physiopathology Pregnancy Complications/immunology Pregnancy Complications/physiopathology Pregnancy Outcome MAC MED MAF MAC MED Pregnancy Retrospective Studies |
title_short |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center |
title_full |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center |
title_fullStr |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center |
title_full_unstemmed |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center |
title_sort |
Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center |
author |
Ambrósio, P |
author_facet |
Ambrósio, P Lermann, R Cordeiro, A Borges, A Nogueira, I Serrano, F |
author_role |
author |
author2 |
Lermann, R Cordeiro, A Borges, A Nogueira, I Serrano, F |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Ambrósio, P Lermann, R Cordeiro, A Borges, A Nogueira, I Serrano, F |
dc.subject.por.fl_str_mv |
Lupus Erythematosus, Systemic/complications Lupus Erythematosus, Systemic/physiopathology Pregnancy Complications/immunology Pregnancy Complications/physiopathology Pregnancy Outcome MAC MED MAF MAC MED Pregnancy Retrospective Studies |
topic |
Lupus Erythematosus, Systemic/complications Lupus Erythematosus, Systemic/physiopathology Pregnancy Complications/immunology Pregnancy Complications/physiopathology Pregnancy Outcome MAC MED MAF MAC MED Pregnancy Retrospective Studies |
description |
This retrospective study was designed to evaluate the outcome of pregnancies in women diagnosed with systemic lupus erythematosus (SLE) followed in a tertiary fetal–maternal center. Data were collected from clinical charts between January 1993 and December 2007, with a total of 136 pregnancies (107 patients). Mean maternal age was 29 years, with the vast majority of patients being Caucasian. Most patients were in remission 6 months prior to pregnancy (93%) and the most frequently affected organs were the skin and joints. Renal lupus accounted for 14% of all cases. Twenty-nine percent of patients were positive for at least one antiphospholid antibody (aPL) and nearly 50% had positive SSa/SSb antibodies. All patients with positive aPL received low-dosage aspirin and low molecular- weight heparin (LMWH). There were no pregnancy complications in more than 50% of cases and hypertensive disease and intrauterine growth restriction were the most common adverse events. There were 125 live births, one neonatal death, eight miscarriages, and three medical terminations of pregnancy. Preterm delivery occurred in 25% of pregnancies. Our results are probably the conjoined result of a multidisciplinary approach together with a systematic management of SLE pregnancies, with most patients keeping their prior SLE medication combined with low-dosage aspirin and LMWH in the presence of aPL. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2010-01-01T00:00:00Z 2012-10-30T15:26:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/705 |
url |
http://hdl.handle.net/10400.17/705 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clin Rev Allergy Immunol. 2010 Apr;38(2-3):77-81 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131281144938496 |