Prediction of Adverse Pregnancy Outcomes in Women with Systemic Lupus Erythematosus

• Autor(a) principal: Palma dos Reis, C
• Data de Publicação: 2020
• Outros Autores: Cardoso, G, Carvalho, C, Nogueira, I, Borges, A, Serrano, F
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.17/3742
• topic: MAC GIN; MAC MED; Adult; Antibodies, Antiphospholipid / blood; Antibodies, Antiphospholipid / immunology; Autoimmunity; Biomarkers; Female; Humans; Enzyme-Linked Immunosorbent Assay; Fetal Growth Retardation / diagnosis; Fetal Growth Retardation / etiology; Lupus Erythematosus, Systemic / diagnosis; Lupus Erythematosus, Systemic / epidemiology; Lupus Erythematosus, Systemic / immunology; Middle Aged; Pre-Eclampsia / diagnosis; Pre-Eclampsia / etiology; Young Adult; Pregnancy; Pregnancy Complications / diagnosis; Pregnancy Complications / epidemiology*; Pregnancy Outcome / epidemiology*; Retrospective Studies

Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease associated with major obstetrical complications such as gestational loss, preterm delivery, fetal growth restriction (FGR) and preeclampsia. Published literature is not consensual regarding the main risk factors for each of these outcomes. Our goal with this study was to determine the most important predictors for each of the main adverse pregnancy outcomes in this population. We conducted a retrospective cohort study of unifetal pregnancies of women with the diagnosis of SLE followed in our unit between January 1994 and December 2016. We excluded elective terminations of pregnancy and cases lost to follow-up and we analyzed 157 pregnancies (128 women). Multiple logistic regression models for the outcomes gestational loss, preterm delivery, fetal growth restriction, and preeclampsia were built. Two-sided p-values of < 0.05 were used to determine statistical significance, and two-sided confidence intervals of 95% are reported. In our cohort, the main risk factors for gestational loss were maternal age and the presence of antiphospholipid antibodies. Lupic nephritis was predictive of a preterm delivery and preeclampsia. Renal involvement and lupus flares during pregnancy were risk factors for FGR. Overall, the main risk factor for an adverse pregnancy outcome were lupus flares during pregnancy. Despite optimal pregnancy monitoring, women with SLE are still at risk for adverse pregnancy outcomes. Risk stratification for each of these outcomes is crucial for an effective counselling and tailored monitoring.