Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems

Detalhes bibliográficos
Autor(a) principal: Ferreira, Inês João
Data de Publicação: 2023
Outros Autores: Paiva, Alexandre, Diniz, Mário, Duarte, Ana Rita
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154558
Resumo: info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT Publisher Copyright: © 2023, The Author(s).
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spelling Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systemsCytotoxicityDeep eutectic systemsEnvironmental toxicityGreen solventsEnvironmental ChemistryPollutionHealth, Toxicology and Mutagenesisinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT Publisher Copyright: © 2023, The Author(s).Deep eutectic systems (DES) have shown increasing popularity in last decade; however, the number of studies on the potential toxicity towards living organisms remains scarce. These studies are of the utmost importance to infer on the claimed non-toxicity and biocompatibility of DES. Most articles published, at this moment, only evaluate the toxicity towards a cell model or in different strains of bacteria. For this purpose, in this work, the effect of two DES (betaine:sorbitol:water 1:1:3 and betaine:glycerol 1:2) and their individual components were evaluated at different concentrations after administered via intraperitoneal injection in zebrafish (Danio rerio). The total antioxidant capacity, lipoperoxidation, and the activity of various enzymes that work in different antioxidant pathways (superoxide dismutase, glutathione peroxidase, catalase, and glutathione S-transferase) were assessed. The results show no significant toxicity within the tested concentrations: up to 5000 µM and 3000 µM, for the assays using the system betaine:sorbitol:water 1:1:3 and for betaine:glycerol 1:2, respectively. The toxicity of individual components was studied up to 1000 µM. Based on the encouraging results that have been obtained, it is safe to conclude that these two deep eutectic systems can be used as the new class of environmentally friendly solvents. Graphical Abstract: [Figure not available: see fulltext.]DQ - Departamento de QuímicaLAQV@REQUIMTEUCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNFerreira, Inês JoãoPaiva, AlexandreDiniz, MárioDuarte, Ana Rita2023-06-28T22:18:10Z2023-032023-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/154558eng0944-1344PURE: 64724251https://doi.org/10.1007/s11356-022-25000-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:58Zoai:run.unl.pt:10362/154558Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:40.054685Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
title Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
spellingShingle Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
Ferreira, Inês João
Cytotoxicity
Deep eutectic systems
Environmental toxicity
Green solvents
Environmental Chemistry
Pollution
Health, Toxicology and Mutagenesis
title_short Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
title_full Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
title_fullStr Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
title_full_unstemmed Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
title_sort Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systems
author Ferreira, Inês João
author_facet Ferreira, Inês João
Paiva, Alexandre
Diniz, Mário
Duarte, Ana Rita
author_role author
author2 Paiva, Alexandre
Diniz, Mário
Duarte, Ana Rita
author2_role author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Ferreira, Inês João
Paiva, Alexandre
Diniz, Mário
Duarte, Ana Rita
dc.subject.por.fl_str_mv Cytotoxicity
Deep eutectic systems
Environmental toxicity
Green solvents
Environmental Chemistry
Pollution
Health, Toxicology and Mutagenesis
topic Cytotoxicity
Deep eutectic systems
Environmental toxicity
Green solvents
Environmental Chemistry
Pollution
Health, Toxicology and Mutagenesis
description info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT Publisher Copyright: © 2023, The Author(s).
publishDate 2023
dc.date.none.fl_str_mv 2023-06-28T22:18:10Z
2023-03
2023-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154558
url http://hdl.handle.net/10362/154558
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0944-1344
PURE: 64724251
https://doi.org/10.1007/s11356-022-25000-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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