Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.26/29349 |
Resumo: | Objective: to investigate the presence of eosinophils in oral intraepithelial neoplasia (OIN) and oral squamous cell carcinoma (OSCC) lesions and its relation to invasion. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasionOral epithelial dysplasiaOral intraepithelial neoplasiaOral squamous cell carcinomaTissue eosinophiliaObjective: to investigate the presence of eosinophils in oral intraepithelial neoplasia (OIN) and oral squamous cell carcinoma (OSCC) lesions and its relation to invasion.Subjects and methods: ninety‐nine oral biopsies were selected and subdivided into the following: OIN‐1(16 cases), OIN‐2 (18 cases), OIN‐3 (17 cases), microinvasive OSCC (10 cases), non‐metastatic OSCC (22 cases) and metastatic OSCC (16 cases). The tissue eosinophilia was evaluated histologically in slices stained with haematoxylin and eosin.Results: Eosinophil distribution was associated with diagnosis severity (p < .01). A significant difference was found between OIN‐3 or microinvasive OSCC and non‐metastatic or metastatic OSCC. Stromal invasion threshold was 7 eos/10 high power field (hpf) (96.1% specificity and 62.5% sensitivity). Eosinophils were absent in OIN‐1; in OIN‐2, two cases were positive. In OIN‐3, five cases showed tissue eosinophilia, four of which had ≥3 eos/hpf or ≥7 eos/10 hpf. Three cases were suspected of invasion; two had a previous history of OSCC with elevated eosinophil infiltrate. In microinvasive OSCC, the four positive cases presented ≥3 eos/hpf and ≥7 eos/10 hpf. Although not significantly different, non‐metastatic invasive OSCC had a higher number of cases (68.2%) with ≥22 eos/10 hpf contrasting with 50% in metastatic OSCC.Conclusion: our results suggest that eosinophils can be considered an indicator of invasion in OIN, helping in cases of difficult diagnosis.John Wiley and SonsRepositório ComumMartinelli-Kläy, C. P.Lombardi, T.Mendis, B. R. R. N.Soares, E. G.Salvado, F.Courvoisier, D. S.Maurício, Paulo2019-07-25T13:57:02Z2018-02-01T00:00:00Z2018-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/29349engMartinelli‐Kläy, CP, Lombardi, T, Mendis, BRRN, et al. Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion. Oral Dis. 2018; 24: 103– 108. https://doi.org/10.1111/odi.127891601-082510.1111/odi.12789metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:38Zoai:comum.rcaap.pt:10400.26/29349Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:28.644264Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion |
| title |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion |
| spellingShingle |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion Martinelli-Kläy, C. P. Oral epithelial dysplasia Oral intraepithelial neoplasia Oral squamous cell carcinoma Tissue eosinophilia |
| title_short |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion |
| title_full |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion |
| title_fullStr |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion |
| title_full_unstemmed |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion |
| title_sort |
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion |
| author |
Martinelli-Kläy, C. P. |
| author_facet |
Martinelli-Kläy, C. P. Lombardi, T. Mendis, B. R. R. N. Soares, E. G. Salvado, F. Courvoisier, D. S. Maurício, Paulo |
| author_role |
author |
| author2 |
Lombardi, T. Mendis, B. R. R. N. Soares, E. G. Salvado, F. Courvoisier, D. S. Maurício, Paulo |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Comum |
| dc.contributor.author.fl_str_mv |
Martinelli-Kläy, C. P. Lombardi, T. Mendis, B. R. R. N. Soares, E. G. Salvado, F. Courvoisier, D. S. Maurício, Paulo |
| dc.subject.por.fl_str_mv |
Oral epithelial dysplasia Oral intraepithelial neoplasia Oral squamous cell carcinoma Tissue eosinophilia |
| topic |
Oral epithelial dysplasia Oral intraepithelial neoplasia Oral squamous cell carcinoma Tissue eosinophilia |
| description |
Objective: to investigate the presence of eosinophils in oral intraepithelial neoplasia (OIN) and oral squamous cell carcinoma (OSCC) lesions and its relation to invasion. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-02-01T00:00:00Z 2018-02-01T00:00:00Z 2019-07-25T13:57:02Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/29349 |
| url |
http://hdl.handle.net/10400.26/29349 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Martinelli‐Kläy, CP, Lombardi, T, Mendis, BRRN, et al. Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion. Oral Dis. 2018; 24: 103– 108. https://doi.org/10.1111/odi.12789 1601-0825 10.1111/odi.12789 |
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metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
John Wiley and Sons |
| publisher.none.fl_str_mv |
John Wiley and Sons |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129964672450560 |