Skeletal muscle adipose tissue tumor axis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/20.500.11960/3046 |
Resumo: | Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo- and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer. |
id |
RCAP_1d6614c60b98df9395245cdaace86031 |
---|---|
oai_identifier_str |
oai:repositorio.ipvc.pt:20.500.11960/3046 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Skeletal muscle adipose tissue tumor axisPhysical activityCancerTumor microenvironmentVisceral adiposityPeriprostatic fatSkeletal muscleIncreased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo- and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.2022-12-29T12:18:36Z2021-04-25T00:00:00Z2021-04-252022-11-15T17:24:10Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.11960/3046eng1661-65961422-006710.3390/ijms22094469Rocha-Rodrigues, SílviaMatos, AndreiaAfonso, JoséMendes-Ferreira, MiguelAbade, EduardoTeixeira, EduardoSilva, BrunoMurawska-Cialowicz, EugeniaOliveira, Maria JoséRibeiro, Ricardoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-21T14:33:05Zoai:repositorio.ipvc.pt:20.500.11960/3046Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:43:01.325533Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Skeletal muscle adipose tissue tumor axis |
title |
Skeletal muscle adipose tissue tumor axis |
spellingShingle |
Skeletal muscle adipose tissue tumor axis Rocha-Rodrigues, Sílvia Physical activity Cancer Tumor microenvironment Visceral adiposity Periprostatic fat Skeletal muscle |
title_short |
Skeletal muscle adipose tissue tumor axis |
title_full |
Skeletal muscle adipose tissue tumor axis |
title_fullStr |
Skeletal muscle adipose tissue tumor axis |
title_full_unstemmed |
Skeletal muscle adipose tissue tumor axis |
title_sort |
Skeletal muscle adipose tissue tumor axis |
author |
Rocha-Rodrigues, Sílvia |
author_facet |
Rocha-Rodrigues, Sílvia Matos, Andreia Afonso, José Mendes-Ferreira, Miguel Abade, Eduardo Teixeira, Eduardo Silva, Bruno Murawska-Cialowicz, Eugenia Oliveira, Maria José Ribeiro, Ricardo |
author_role |
author |
author2 |
Matos, Andreia Afonso, José Mendes-Ferreira, Miguel Abade, Eduardo Teixeira, Eduardo Silva, Bruno Murawska-Cialowicz, Eugenia Oliveira, Maria José Ribeiro, Ricardo |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha-Rodrigues, Sílvia Matos, Andreia Afonso, José Mendes-Ferreira, Miguel Abade, Eduardo Teixeira, Eduardo Silva, Bruno Murawska-Cialowicz, Eugenia Oliveira, Maria José Ribeiro, Ricardo |
dc.subject.por.fl_str_mv |
Physical activity Cancer Tumor microenvironment Visceral adiposity Periprostatic fat Skeletal muscle |
topic |
Physical activity Cancer Tumor microenvironment Visceral adiposity Periprostatic fat Skeletal muscle |
description |
Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo- and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-25T00:00:00Z 2021-04-25 2022-12-29T12:18:36Z 2022-11-15T17:24:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/20.500.11960/3046 |
url |
http://hdl.handle.net/20.500.11960/3046 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1661-6596 1422-0067 10.3390/ijms22094469 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131515955707904 |