CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases

Detalhes bibliográficos
Autor(a) principal: Lages, Marlene
Data de Publicação: 2021
Outros Autores: Carvalho, Lucinda, Feijó, Salvato, Vieira, Alexandra, Fonseca-Pinto, Rui, Guarino, Maria Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/7128
Resumo: Early screening of metabolic diseases is crucial since continued undiagnostic places an ever-increasing burden on healthcare systems. Recent studies suggest a link between overactivated carotid bodies (CB) and the genesis of type 2 diabetes mellitus. The non-invasive assessment of CB activity by measuring ventilatory, cardiac and metabolic responses to challenge tests may have predictive value for metabolic diseases; however, there are no commercially available devices that assess CB activity. The findings of the CBmeter study will clarify the role of the CBs in the genesis of—metabolic diseases and guide the development of new therapeutic approaches for early intervention in metabolic disturbances. Results may also contribute to patient classification and stratification for future CB modulatory interventions.
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spelling CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseasesEarly screening of metabolic diseases is crucial since continued undiagnostic places an ever-increasing burden on healthcare systems. Recent studies suggest a link between overactivated carotid bodies (CB) and the genesis of type 2 diabetes mellitus. The non-invasive assessment of CB activity by measuring ventilatory, cardiac and metabolic responses to challenge tests may have predictive value for metabolic diseases; however, there are no commercially available devices that assess CB activity. The findings of the CBmeter study will clarify the role of the CBs in the genesis of—metabolic diseases and guide the development of new therapeutic approaches for early intervention in metabolic disturbances. Results may also contribute to patient classification and stratification for future CB modulatory interventions.BMJ Publishing GroupIC-OnlineLages, MarleneCarvalho, LucindaFeijó, SalvatoVieira, AlexandraFonseca-Pinto, RuiGuarino, Maria Pedro2022-05-13T09:11:08Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/7128engLages M, Carvalho L, Feijó S, et al. CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases. BMJ Open 2021;11:e042825. doi:10.1136/ bmjopen-2020-04282510.1136/bmjopen-2020-0428252044-6055info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:53:42Zoai:iconline.ipleiria.pt:10400.8/7128Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:51.816762Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
title CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
spellingShingle CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
Lages, Marlene
title_short CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
title_full CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
title_fullStr CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
title_full_unstemmed CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
title_sort CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
author Lages, Marlene
author_facet Lages, Marlene
Carvalho, Lucinda
Feijó, Salvato
Vieira, Alexandra
Fonseca-Pinto, Rui
Guarino, Maria Pedro
author_role author
author2 Carvalho, Lucinda
Feijó, Salvato
Vieira, Alexandra
Fonseca-Pinto, Rui
Guarino, Maria Pedro
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Lages, Marlene
Carvalho, Lucinda
Feijó, Salvato
Vieira, Alexandra
Fonseca-Pinto, Rui
Guarino, Maria Pedro
description Early screening of metabolic diseases is crucial since continued undiagnostic places an ever-increasing burden on healthcare systems. Recent studies suggest a link between overactivated carotid bodies (CB) and the genesis of type 2 diabetes mellitus. The non-invasive assessment of CB activity by measuring ventilatory, cardiac and metabolic responses to challenge tests may have predictive value for metabolic diseases; however, there are no commercially available devices that assess CB activity. The findings of the CBmeter study will clarify the role of the CBs in the genesis of—metabolic diseases and guide the development of new therapeutic approaches for early intervention in metabolic disturbances. Results may also contribute to patient classification and stratification for future CB modulatory interventions.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-05-13T09:11:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/7128
url http://hdl.handle.net/10400.8/7128
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lages M, Carvalho L, Feijó S, et al. CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases. BMJ Open 2021;11:e042825. doi:10.1136/ bmjopen-2020-042825
10.1136/bmjopen-2020-042825
2044-6055
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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