CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/7128 |
Resumo: | Early screening of metabolic diseases is crucial since continued undiagnostic places an ever-increasing burden on healthcare systems. Recent studies suggest a link between overactivated carotid bodies (CB) and the genesis of type 2 diabetes mellitus. The non-invasive assessment of CB activity by measuring ventilatory, cardiac and metabolic responses to challenge tests may have predictive value for metabolic diseases; however, there are no commercially available devices that assess CB activity. The findings of the CBmeter study will clarify the role of the CBs in the genesis of—metabolic diseases and guide the development of new therapeutic approaches for early intervention in metabolic disturbances. Results may also contribute to patient classification and stratification for future CB modulatory interventions. |
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spelling |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseasesEarly screening of metabolic diseases is crucial since continued undiagnostic places an ever-increasing burden on healthcare systems. Recent studies suggest a link between overactivated carotid bodies (CB) and the genesis of type 2 diabetes mellitus. The non-invasive assessment of CB activity by measuring ventilatory, cardiac and metabolic responses to challenge tests may have predictive value for metabolic diseases; however, there are no commercially available devices that assess CB activity. The findings of the CBmeter study will clarify the role of the CBs in the genesis of—metabolic diseases and guide the development of new therapeutic approaches for early intervention in metabolic disturbances. Results may also contribute to patient classification and stratification for future CB modulatory interventions.BMJ Publishing GroupIC-OnlineLages, MarleneCarvalho, LucindaFeijó, SalvatoVieira, AlexandraFonseca-Pinto, RuiGuarino, Maria Pedro2022-05-13T09:11:08Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/7128engLages M, Carvalho L, Feijó S, et al. CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases. BMJ Open 2021;11:e042825. doi:10.1136/ bmjopen-2020-04282510.1136/bmjopen-2020-0428252044-6055info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:53:42Zoai:iconline.ipleiria.pt:10400.8/7128Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:51.816762Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases |
title |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases |
spellingShingle |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases Lages, Marlene |
title_short |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases |
title_full |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases |
title_fullStr |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases |
title_full_unstemmed |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases |
title_sort |
CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases |
author |
Lages, Marlene |
author_facet |
Lages, Marlene Carvalho, Lucinda Feijó, Salvato Vieira, Alexandra Fonseca-Pinto, Rui Guarino, Maria Pedro |
author_role |
author |
author2 |
Carvalho, Lucinda Feijó, Salvato Vieira, Alexandra Fonseca-Pinto, Rui Guarino, Maria Pedro |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Lages, Marlene Carvalho, Lucinda Feijó, Salvato Vieira, Alexandra Fonseca-Pinto, Rui Guarino, Maria Pedro |
description |
Early screening of metabolic diseases is crucial since continued undiagnostic places an ever-increasing burden on healthcare systems. Recent studies suggest a link between overactivated carotid bodies (CB) and the genesis of type 2 diabetes mellitus. The non-invasive assessment of CB activity by measuring ventilatory, cardiac and metabolic responses to challenge tests may have predictive value for metabolic diseases; however, there are no commercially available devices that assess CB activity. The findings of the CBmeter study will clarify the role of the CBs in the genesis of—metabolic diseases and guide the development of new therapeutic approaches for early intervention in metabolic disturbances. Results may also contribute to patient classification and stratification for future CB modulatory interventions. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-05-13T09:11:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/7128 |
url |
http://hdl.handle.net/10400.8/7128 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lages M, Carvalho L, Feijó S, et al. CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases. BMJ Open 2021;11:e042825. doi:10.1136/ bmjopen-2020-042825 10.1136/bmjopen-2020-042825 2044-6055 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMJ Publishing Group |
publisher.none.fl_str_mv |
BMJ Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136990718853120 |