TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.48560/rspo.13684 |
Resumo: | PURPOSE - To correlate the morphological characteristics of diabetic retinal microaneurysms on spectral domain optical coherence tomography (SD-OCT) with their functional leakage status on fluorescein angiography (FA) in a simultaneous assessment.. METHODS – In this retrospective observational study, 88 retinal microaneurysms in 11 eyes of 6 type 2 diabetic adult patients with diabetic retinopathy (DR) (8 moderate non proliferative DR and 3 proliferative DR) were analyzed with simultaneous FA and SD-OCT imaging. Their morphological characteristics in SD-OCT, including shape, presence of a capsule-like structure, diameter, lumen reflectivity and the presence of nearby cysts were correlated with the leaking pattern (classified as absent, mild or intense). RESULTS - The majority of the microaneurysms were oval in shape (86,4%), with no “capsule” (84.1%), with an heterogeneous lumen reflectivity (85.2%) and no associated cysts (65.9%). Their location in relation to the internal and external retinal boundaries (p=0.011) as well as nearby cysts (p<0.001) were correlated with angiographic leakage. No significant association was found between size, presence of a “capsule” and internal reflectivity on SD-OCT with the FA leakage status. Microaneurysms associated with cysts had larger vertical (p=0.001) and horizontal diameters (p<0.001). CONCLUSIONS – A significant correlation was found between the presence of cystoid spaces in SD-OCT and detectable leakage on FA. In addition, cysts were found to be more frequent in the presence of larger microaneurysms, which may add some useful information regarding the pathophysiology of diabetic macular edema. The identification of high risk microaneurysms on SD OCT may help to establish a customized and more cost-effective strategy for follow-up and treatment in diabetic patients, without the need for invasive contrast imaging or OCT-angiography. |
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TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORTArtigos OriginaisPURPOSE - To correlate the morphological characteristics of diabetic retinal microaneurysms on spectral domain optical coherence tomography (SD-OCT) with their functional leakage status on fluorescein angiography (FA) in a simultaneous assessment.. METHODS – In this retrospective observational study, 88 retinal microaneurysms in 11 eyes of 6 type 2 diabetic adult patients with diabetic retinopathy (DR) (8 moderate non proliferative DR and 3 proliferative DR) were analyzed with simultaneous FA and SD-OCT imaging. Their morphological characteristics in SD-OCT, including shape, presence of a capsule-like structure, diameter, lumen reflectivity and the presence of nearby cysts were correlated with the leaking pattern (classified as absent, mild or intense). RESULTS - The majority of the microaneurysms were oval in shape (86,4%), with no “capsule” (84.1%), with an heterogeneous lumen reflectivity (85.2%) and no associated cysts (65.9%). Their location in relation to the internal and external retinal boundaries (p=0.011) as well as nearby cysts (p<0.001) were correlated with angiographic leakage. No significant association was found between size, presence of a “capsule” and internal reflectivity on SD-OCT with the FA leakage status. Microaneurysms associated with cysts had larger vertical (p=0.001) and horizontal diameters (p<0.001). CONCLUSIONS – A significant correlation was found between the presence of cystoid spaces in SD-OCT and detectable leakage on FA. In addition, cysts were found to be more frequent in the presence of larger microaneurysms, which may add some useful information regarding the pathophysiology of diabetic macular edema. The identification of high risk microaneurysms on SD OCT may help to establish a customized and more cost-effective strategy for follow-up and treatment in diabetic patients, without the need for invasive contrast imaging or OCT-angiography.Ajnet2019-01-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.48560/rspo.13684eng1646-69501646-6950Leandro, João Estevesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-22T17:06:05Zoai:ojs.revistas.rcaap.pt:article/13684Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:01:41.341484Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT |
title |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT |
spellingShingle |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT Leandro, João Esteves Artigos Originais |
title_short |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT |
title_full |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT |
title_fullStr |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT |
title_full_unstemmed |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT |
title_sort |
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES OF DIABETIC RETINAL MICROANEURYSMS: A SIMULTANEOUS STUDY REPORT |
author |
Leandro, João Esteves |
author_facet |
Leandro, João Esteves |
author_role |
author |
dc.contributor.author.fl_str_mv |
Leandro, João Esteves |
dc.subject.por.fl_str_mv |
Artigos Originais |
topic |
Artigos Originais |
description |
PURPOSE - To correlate the morphological characteristics of diabetic retinal microaneurysms on spectral domain optical coherence tomography (SD-OCT) with their functional leakage status on fluorescein angiography (FA) in a simultaneous assessment.. METHODS – In this retrospective observational study, 88 retinal microaneurysms in 11 eyes of 6 type 2 diabetic adult patients with diabetic retinopathy (DR) (8 moderate non proliferative DR and 3 proliferative DR) were analyzed with simultaneous FA and SD-OCT imaging. Their morphological characteristics in SD-OCT, including shape, presence of a capsule-like structure, diameter, lumen reflectivity and the presence of nearby cysts were correlated with the leaking pattern (classified as absent, mild or intense). RESULTS - The majority of the microaneurysms were oval in shape (86,4%), with no “capsule” (84.1%), with an heterogeneous lumen reflectivity (85.2%) and no associated cysts (65.9%). Their location in relation to the internal and external retinal boundaries (p=0.011) as well as nearby cysts (p<0.001) were correlated with angiographic leakage. No significant association was found between size, presence of a “capsule” and internal reflectivity on SD-OCT with the FA leakage status. Microaneurysms associated with cysts had larger vertical (p=0.001) and horizontal diameters (p<0.001). CONCLUSIONS – A significant correlation was found between the presence of cystoid spaces in SD-OCT and detectable leakage on FA. In addition, cysts were found to be more frequent in the presence of larger microaneurysms, which may add some useful information regarding the pathophysiology of diabetic macular edema. The identification of high risk microaneurysms on SD OCT may help to establish a customized and more cost-effective strategy for follow-up and treatment in diabetic patients, without the need for invasive contrast imaging or OCT-angiography. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-18T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.48560/rspo.13684 |
url |
https://doi.org/10.48560/rspo.13684 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1646-6950 1646-6950 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Ajnet |
publisher.none.fl_str_mv |
Ajnet |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130481923457024 |