Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.48560/rspo.28261 |
Resumo: | INTRODUCTION: The prevalence of myopia is expected to increase significantly in the following decades. Moreover, axial myopia is associated with rhegmatogenous retinal detachment (RRD), a major cause of visual impairment in these patients. RRD develops after the dynamic interaction between the vitreous and the retina. Axial length (AL) is a well-described risk factor, but alone is insufficient to predict RRD. The main aim of this study was to analyze, dynamically and in vivo, ocular biomechanics in high myopic patients with RRD. Our secondary outcome was to address demographic, biometric and biomechanical predictors of RRD. METHODS: Observational cross-sectional case-control study, set in the Surgical Retina Clinic, Ophthalmology Department, Centro Hospitalar e Universitário do Porto, Portugal, that included subjects with myopia and history of RRD in one eye (RRD group), together with a control group of age and AL-matched subjects with no history of retinal tear or RRD in any eye. In the RRD group, only the fellow non-RRD non-operated eye was included for analysis. Biomechanical assessment was performed with Corvis Scheimpflung Technology® (Oculus, Germany) and AL was measured with Anterion® (Heidelberg, Germany). RESULTS: This study included for analysis 34 subjects (17 eyes of 17 patients in each group). Age (p=0.959), AL (p=0.879) and intraocular pressure (p=0.489) were well matched between groups. A multivariable logistic regression confirmed an independent effect of A1 Deflection Amplitude (standardized coefficient = -1.096, Wald test p-value=0.027), HC time (-1.207, p=0.030), and height (1.554, p=0.030) on RRD, with an area under the curve in the ROC analysis for this model of 0.897. We found no association between biometric or biomechanical parameters and the characteristics of RRD or final best-corrected visual acuity. CONCLUSION: To our knowledge, this is the first study evaluating in vivo ocular biomechanics in the development of RRD. We observed that the eyes of patients with RRD have stiffer measured biomechanics when compared to controls. The different biomechanical behavior between the vitreous and the sclera (to which the retina is ultimately attached) results in higher shear stress at the vitreoretinal interface. We hypothesize that RRD develops in cases where this balance is disrupted by a stiff sclera on one side and a compact vitreous on the other. The association between body height and RRD may also relate to systemic genetically determined biomechanics. |
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Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic PatientsPreditores Biomecânicos de Descolamento de Retina em Doentes com Alta MiopiaArtigos OriginaisINTRODUCTION: The prevalence of myopia is expected to increase significantly in the following decades. Moreover, axial myopia is associated with rhegmatogenous retinal detachment (RRD), a major cause of visual impairment in these patients. RRD develops after the dynamic interaction between the vitreous and the retina. Axial length (AL) is a well-described risk factor, but alone is insufficient to predict RRD. The main aim of this study was to analyze, dynamically and in vivo, ocular biomechanics in high myopic patients with RRD. Our secondary outcome was to address demographic, biometric and biomechanical predictors of RRD. METHODS: Observational cross-sectional case-control study, set in the Surgical Retina Clinic, Ophthalmology Department, Centro Hospitalar e Universitário do Porto, Portugal, that included subjects with myopia and history of RRD in one eye (RRD group), together with a control group of age and AL-matched subjects with no history of retinal tear or RRD in any eye. In the RRD group, only the fellow non-RRD non-operated eye was included for analysis. Biomechanical assessment was performed with Corvis Scheimpflung Technology® (Oculus, Germany) and AL was measured with Anterion® (Heidelberg, Germany). RESULTS: This study included for analysis 34 subjects (17 eyes of 17 patients in each group). Age (p=0.959), AL (p=0.879) and intraocular pressure (p=0.489) were well matched between groups. A multivariable logistic regression confirmed an independent effect of A1 Deflection Amplitude (standardized coefficient = -1.096, Wald test p-value=0.027), HC time (-1.207, p=0.030), and height (1.554, p=0.030) on RRD, with an area under the curve in the ROC analysis for this model of 0.897. We found no association between biometric or biomechanical parameters and the characteristics of RRD or final best-corrected visual acuity. CONCLUSION: To our knowledge, this is the first study evaluating in vivo ocular biomechanics in the development of RRD. We observed that the eyes of patients with RRD have stiffer measured biomechanics when compared to controls. The different biomechanical behavior between the vitreous and the sclera (to which the retina is ultimately attached) results in higher shear stress at the vitreoretinal interface. We hypothesize that RRD develops in cases where this balance is disrupted by a stiff sclera on one side and a compact vitreous on the other. The association between body height and RRD may also relate to systemic genetically determined biomechanics.INTRODUÇÃO: É expectável que a prevalência da miopia aumente nas próximas décadas. Além disso, a miopia axial está associada a descolamento de retina (DR), uma causa importante de défice visual nesses doentes. O DR desenvolve-se a partir da interação dinâmica entre o vítreo e a retina. O comprimento axial (CA) é um fator de risco bem descrito, mas isoladamente é insuficiente para prever o DR. O objetivo principal desde estudo foi analisar, dinamicamente e in vivo, a biomecânica ocular em doentes com miopia e DR. MÉTODOS: Estudo transversal caso-controlo, na secção de Retina Cirúrgica do Serviço de Oftalmologia do Centro Hospitalar Universitário do Porto, que incluiu participantes com AM e antecedentes DR em um dos olhos (grupo DR), juntamente com um grupo de controlo com participantes com idade e CA emparelhados, mas sem antecedentes de rasgadura de retina ou DR em nenhum dos olhos. No grupo DR, apenas o olho adelfo (sem antecedentes de DR ou cirúrgica intraocular) foi incluído para a análise. A analise da biomecânica ocular foi realizada com Corvis Scheimpflung Technology® (Oculus, Germany) e AL foi medido com o Anterion® (Heidelberg, Germany). RESULTADOS: O estudo incluiu para análise 34 participantes (17 olhos de 17 participantes em cada grupo). A idade (p=0,959), o CA (p=0,879) e a pressão intraocular (p=0,489) não foram diferentes e estavam bem emparelhados entre os grupos. Uma análise de regressão logística multivariável confirmou o efeito independente da amplitude de deflexão A1 (coeficiente padronizado = -1,096, p-value do teste de Wald = 0,027), tempo HC (-1,207, p=0,030) e altura corporal (1,554, p=0,030) no DR, com área sob a curva da análise ROC deste modelo de 0,897. Não foram encontradas associações entre parâmetros biométricos ou biomecânicos e as características do DR (localização, severidade, presença de paliçadas) ou com a melhor acuidade visual corrigida final. CONCLUSÃO: Este é o primeiro estudo a avaliar in vivo a biomecânica ocular na fisiopatologia do DR. Observámos que os olhos de doentes com DR apresentaram medições biomecânicas tendencialmente mais rígidas quando comparados com o grupo de controlo. O diferente comportamento entre o vítreo e a esclerótica (à qual a retina se liga em última instância) resulta numa tensão de cisalhamento ao nível da interface vítreo-retiniana. O DR desenvolve-se em casos em que este balanço é quebrado pela esclerótica rígida de um lado e o humor vítreo compacto do outro. A associação entre a altura corporal e o DR pode também estar associada à biomecânica.Ajnet2023-12-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.48560/rspo.28261eng1646-69501646-6950Marques, João HeitorBaptista, Pedro ManuelMarta, AnaSousa, PauloPires, SaulMeireles, AngelinaAmbrósio, RenatoMenéres, PedroMelo Beirão, Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-04T20:30:31Zoai:ojs.revistas.rcaap.pt:article/28261Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:30:07.910466Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients Preditores Biomecânicos de Descolamento de Retina em Doentes com Alta Miopia |
title |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients |
spellingShingle |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients Marques, João Heitor Artigos Originais |
title_short |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients |
title_full |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients |
title_fullStr |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients |
title_full_unstemmed |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients |
title_sort |
Biomechanical Predictors of Rhegmatogenous Retinal Detachment in Myopic Patients |
author |
Marques, João Heitor |
author_facet |
Marques, João Heitor Baptista, Pedro Manuel Marta, Ana Sousa, Paulo Pires, Saul Meireles, Angelina Ambrósio, Renato Menéres, Pedro Melo Beirão, João |
author_role |
author |
author2 |
Baptista, Pedro Manuel Marta, Ana Sousa, Paulo Pires, Saul Meireles, Angelina Ambrósio, Renato Menéres, Pedro Melo Beirão, João |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Marques, João Heitor Baptista, Pedro Manuel Marta, Ana Sousa, Paulo Pires, Saul Meireles, Angelina Ambrósio, Renato Menéres, Pedro Melo Beirão, João |
dc.subject.por.fl_str_mv |
Artigos Originais |
topic |
Artigos Originais |
description |
INTRODUCTION: The prevalence of myopia is expected to increase significantly in the following decades. Moreover, axial myopia is associated with rhegmatogenous retinal detachment (RRD), a major cause of visual impairment in these patients. RRD develops after the dynamic interaction between the vitreous and the retina. Axial length (AL) is a well-described risk factor, but alone is insufficient to predict RRD. The main aim of this study was to analyze, dynamically and in vivo, ocular biomechanics in high myopic patients with RRD. Our secondary outcome was to address demographic, biometric and biomechanical predictors of RRD. METHODS: Observational cross-sectional case-control study, set in the Surgical Retina Clinic, Ophthalmology Department, Centro Hospitalar e Universitário do Porto, Portugal, that included subjects with myopia and history of RRD in one eye (RRD group), together with a control group of age and AL-matched subjects with no history of retinal tear or RRD in any eye. In the RRD group, only the fellow non-RRD non-operated eye was included for analysis. Biomechanical assessment was performed with Corvis Scheimpflung Technology® (Oculus, Germany) and AL was measured with Anterion® (Heidelberg, Germany). RESULTS: This study included for analysis 34 subjects (17 eyes of 17 patients in each group). Age (p=0.959), AL (p=0.879) and intraocular pressure (p=0.489) were well matched between groups. A multivariable logistic regression confirmed an independent effect of A1 Deflection Amplitude (standardized coefficient = -1.096, Wald test p-value=0.027), HC time (-1.207, p=0.030), and height (1.554, p=0.030) on RRD, with an area under the curve in the ROC analysis for this model of 0.897. We found no association between biometric or biomechanical parameters and the characteristics of RRD or final best-corrected visual acuity. CONCLUSION: To our knowledge, this is the first study evaluating in vivo ocular biomechanics in the development of RRD. We observed that the eyes of patients with RRD have stiffer measured biomechanics when compared to controls. The different biomechanical behavior between the vitreous and the sclera (to which the retina is ultimately attached) results in higher shear stress at the vitreoretinal interface. We hypothesize that RRD develops in cases where this balance is disrupted by a stiff sclera on one side and a compact vitreous on the other. The association between body height and RRD may also relate to systemic genetically determined biomechanics. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.48560/rspo.28261 |
url |
https://doi.org/10.48560/rspo.28261 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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1646-6950 1646-6950 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Ajnet |
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Ajnet |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136783480389632 |