Overview of Drug Allergy: From Immunogenetic Basis to Practice
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092 |
Resumo: | Drug therapy is often a balance between the beneficial and harmful effects of drugs. Drug allergic reactions are adverse reactions mediated by immunological mechanisms and usually not related to the pharmacological actions of the drug. They can be classified based either on the clinical presentation or the underlying immunological mechanism. Although uncommon, drug allergic reactions are unpredictable and can be very severe, even life threatening. The aim of this review was to provide clinicians from different medical specialties with a working tool to improve management of their patients with suspected drug allergy. It was conducted as a nonsystematic review, and attempts to describe the complexity of drug allergy. The information included ranges from pathophysiology to the heterogeneous clinical presentation, with a special focus on the drugs most frequently involved, as well as a classification of reactions and risk factors. Despite all advances in this challenging and complex field of allergy and clinical immunology, drug allergy is not yet fully established and understood. An exceptional contribution was brought by pharmacogenomics, even though a specific pharmacogenetic association has only been defined for a very limited number of drugs. Further studies are needed to obtain clearer answers when managing each individual case of drug allergy. |
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Overview of Drug Allergy: From Immunogenetic Basis to PracticeAlergia a Fármacos: Da Imunogenética à ClínicaDrug Hypersensitivity/etiologyDrug Hypersensitivity/immunologyPharmacogeneticsDrug-Related Side Effects and Adverse ReactionsDrug therapy is often a balance between the beneficial and harmful effects of drugs. Drug allergic reactions are adverse reactions mediated by immunological mechanisms and usually not related to the pharmacological actions of the drug. They can be classified based either on the clinical presentation or the underlying immunological mechanism. Although uncommon, drug allergic reactions are unpredictable and can be very severe, even life threatening. The aim of this review was to provide clinicians from different medical specialties with a working tool to improve management of their patients with suspected drug allergy. It was conducted as a nonsystematic review, and attempts to describe the complexity of drug allergy. The information included ranges from pathophysiology to the heterogeneous clinical presentation, with a special focus on the drugs most frequently involved, as well as a classification of reactions and risk factors. Despite all advances in this challenging and complex field of allergy and clinical immunology, drug allergy is not yet fully established and understood. An exceptional contribution was brought by pharmacogenomics, even though a specific pharmacogenetic association has only been defined for a very limited number of drugs. Further studies are needed to obtain clearer answers when managing each individual case of drug allergy.A terapêutica farmacológica consiste, frequentemente, num equilíbrio entre os efeitos benéficos e prejudiciais dos fármacos. As reações alérgicas a fármacos são reações adversas mediadas por mecanismos imunológicos e não relacionadas com as ações farmacológicas do fármaco. Podem ser classificadas quer com base na apresentação clínica, quer no mecanismo imunológico subjacente. Embora pouco comuns, as reações alérgicas a fármacos são imprevisíveis, podendo ser graves e potencialmente fatais. O objetivo da presente revisão da literatura foi disponibilizar aos clínicos de diversas áreas médicas uma ferramenta de trabalho para uma melhor abordagem dos seus doentes com suspeita de alergia a fármacos. Foi conduzida de forma não sistemática e procura descrever a complexidade das reações alérgicas a fármacos, desde a fisiopatologia à heterogeneidade da apresentação clínica. Foi dado especial destaque aos fármacos mais frequentemente envolvidos, à classificação das reações e aos fatores de risco. Apesar de todos os avanços nesta área desafiante e complexa da alergologia e imunologia clínica, a alergia a fármacos não está ainda completamente compreendida e estabelecida. A farmacogenética trouxe um contributo excecional, embora apenas para um número muito limitado de fármacos esteja definida uma associação farmacogenética. São necessários estudos adicionais que permitam obter respostas mais diretas na abordagem de cada caso individual de alergia a fármacos.Ordem dos Médicos2018-10-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092oai:ojs.www.actamedicaportuguesa.com:article/10092Acta Médica Portuguesa; Vol. 31 No. 10 (2018): October; 581-588Acta Médica Portuguesa; Vol. 31 N.º 10 (2018): Outubro; 581-5881646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/5507https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/10079https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/10080https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/10638Direitos de Autor (c) 2018 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessDias de Castro, EuniceCarolino, FabríciaRibeiro, LauraCernadas, Josefina R.2022-12-20T11:05:52Zoai:ojs.www.actamedicaportuguesa.com:article/10092Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:49.599932Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Overview of Drug Allergy: From Immunogenetic Basis to Practice Alergia a Fármacos: Da Imunogenética à Clínica |
title |
Overview of Drug Allergy: From Immunogenetic Basis to Practice |
spellingShingle |
Overview of Drug Allergy: From Immunogenetic Basis to Practice Dias de Castro, Eunice Drug Hypersensitivity/etiology Drug Hypersensitivity/immunology Pharmacogenetics Drug-Related Side Effects and Adverse Reactions |
title_short |
Overview of Drug Allergy: From Immunogenetic Basis to Practice |
title_full |
Overview of Drug Allergy: From Immunogenetic Basis to Practice |
title_fullStr |
Overview of Drug Allergy: From Immunogenetic Basis to Practice |
title_full_unstemmed |
Overview of Drug Allergy: From Immunogenetic Basis to Practice |
title_sort |
Overview of Drug Allergy: From Immunogenetic Basis to Practice |
author |
Dias de Castro, Eunice |
author_facet |
Dias de Castro, Eunice Carolino, Fabrícia Ribeiro, Laura Cernadas, Josefina R. |
author_role |
author |
author2 |
Carolino, Fabrícia Ribeiro, Laura Cernadas, Josefina R. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Dias de Castro, Eunice Carolino, Fabrícia Ribeiro, Laura Cernadas, Josefina R. |
dc.subject.por.fl_str_mv |
Drug Hypersensitivity/etiology Drug Hypersensitivity/immunology Pharmacogenetics Drug-Related Side Effects and Adverse Reactions |
topic |
Drug Hypersensitivity/etiology Drug Hypersensitivity/immunology Pharmacogenetics Drug-Related Side Effects and Adverse Reactions |
description |
Drug therapy is often a balance between the beneficial and harmful effects of drugs. Drug allergic reactions are adverse reactions mediated by immunological mechanisms and usually not related to the pharmacological actions of the drug. They can be classified based either on the clinical presentation or the underlying immunological mechanism. Although uncommon, drug allergic reactions are unpredictable and can be very severe, even life threatening. The aim of this review was to provide clinicians from different medical specialties with a working tool to improve management of their patients with suspected drug allergy. It was conducted as a nonsystematic review, and attempts to describe the complexity of drug allergy. The information included ranges from pathophysiology to the heterogeneous clinical presentation, with a special focus on the drugs most frequently involved, as well as a classification of reactions and risk factors. Despite all advances in this challenging and complex field of allergy and clinical immunology, drug allergy is not yet fully established and understood. An exceptional contribution was brought by pharmacogenomics, even though a specific pharmacogenetic association has only been defined for a very limited number of drugs. Further studies are needed to obtain clearer answers when managing each individual case of drug allergy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092 oai:ojs.www.actamedicaportuguesa.com:article/10092 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/10092 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/5507 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/10079 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/10080 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10092/10638 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2018 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2018 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
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application/pdf application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
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Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 31 No. 10 (2018): October; 581-588 Acta Médica Portuguesa; Vol. 31 N.º 10 (2018): Outubro; 581-588 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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