Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/6599 |
Resumo: | Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31707201/ |
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Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018Respiratory Syncytial VirusBA9 GenotypeGenetic DiversityMolecular EpidemiologyON1 GenotypePortugalInfecções RespiratóriasFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31707201/Introduction: Respiratory syncytial virus (RSV) is associated with substantial morbidity and mortality since it is a predominant viral agent causing respiratory tract infections in infants, young children and the elderly. Considering the availability of the RSV vaccines in the coming years, molecular understanding in RSV is necessary. Objective: The objective of the present study was to describe RSV epidemiology and genotype variability in Portugal during the 2014/15-2017/18 period. Material and methods: Epidemiological data and RSV-positive samples from patients with a respiratory infection were collected through the non-sentinel and sentinel influenza surveillance system (ISS). RSV detection, subtyping in A and B, and sequencing of the second hypervariable region (HVR2) of G gene were performed by molecular methods. Phylogenetic trees were generated using the Neighbor-Joining method and p-distance model on MEGA 7.0. Results: RSV prevalence varied between the sentinel (2.5%, 97/3891) and the non-sentinel ISS (20.7%, 3138/16779), being higher (P < 0.0001) among children aged <5 years. Bronchiolitis (62.9%, 183/291) and influenza-like illness (24.6%, 14/57) were associated (P < 0.0001) with RSV laboratory confirmation among children aged <6 months and adults ≥65 years, respectively. The HVR2 was sequenced for 562 samples. RSV-A (46.4%, 261/562) and RSV-B (53.6%, 301/562) strains clustered mainly to ON1 (89.2%, 233/261) and BA9 (92%, 277/301) genotypes, respectively, although NA1 and BA10 were also present until 2015/2016. Conclusion: The sequence and phylogenetic analysis reflected the relatively high diversity of Portuguese RSV strains. BA9 and ON1 genotypes, which have been circulating in Portugal since 2010/2011 and 2011/2012 respectively, predominated during the whole study period.ElsevierRepositório Científico do Instituto Nacional de SaúdeSáez-López, EmmaCristóvão, PaulaCosta, InêsPechirra, PedroConde, PatríciaGuiomar, RaquelPeres, Maria JoãoViseu, ReginaLopes, PauloSoares, VâniaVale, FátimaFonseca, PatriciaFreitas, LudivinaAlves, JosePessanha, Maria AnaToscano, CristinaMota-Vieira, LuísaVeloso, Rita CabralCôrte-Real, RitaBranquinho, PaulaPereira‑Vaz, JoãoRodrigues, FernandoCunha, MárioMartins, LuísMota, PaulaCouto, Ana RitaBruges-Armas, JácomeAlmeida, SofiaRodrigues, DéboraPortuguese Laboratory Network for the Diagnosis of Influenza Infection2020-05-05T23:06:26Z2019-10-102019-10-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6599engJ Clin Virol. 2019 Dec;121:104200. doi: 10.1016/j.jcv.2019.104200. Epub 2019 Oct 101386-653210.1016/j.jcv.2019.104200info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:45Zoai:repositorio.insa.pt:10400.18/6599Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:40.729869Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 |
title |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 |
spellingShingle |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 Sáez-López, Emma Respiratory Syncytial Virus BA9 Genotype Genetic Diversity Molecular Epidemiology ON1 Genotype Portugal Infecções Respiratórias |
title_short |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 |
title_full |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 |
title_fullStr |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 |
title_full_unstemmed |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 |
title_sort |
Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018 |
author |
Sáez-López, Emma |
author_facet |
Sáez-López, Emma Cristóvão, Paula Costa, Inês Pechirra, Pedro Conde, Patrícia Guiomar, Raquel Peres, Maria João Viseu, Regina Lopes, Paulo Soares, Vânia Vale, Fátima Fonseca, Patricia Freitas, Ludivina Alves, Jose Pessanha, Maria Ana Toscano, Cristina Mota-Vieira, Luísa Veloso, Rita Cabral Côrte-Real, Rita Branquinho, Paula Pereira‑Vaz, João Rodrigues, Fernando Cunha, Mário Martins, Luís Mota, Paula Couto, Ana Rita Bruges-Armas, Jácome Almeida, Sofia Rodrigues, Débora Portuguese Laboratory Network for the Diagnosis of Influenza Infection |
author_role |
author |
author2 |
Cristóvão, Paula Costa, Inês Pechirra, Pedro Conde, Patrícia Guiomar, Raquel Peres, Maria João Viseu, Regina Lopes, Paulo Soares, Vânia Vale, Fátima Fonseca, Patricia Freitas, Ludivina Alves, Jose Pessanha, Maria Ana Toscano, Cristina Mota-Vieira, Luísa Veloso, Rita Cabral Côrte-Real, Rita Branquinho, Paula Pereira‑Vaz, João Rodrigues, Fernando Cunha, Mário Martins, Luís Mota, Paula Couto, Ana Rita Bruges-Armas, Jácome Almeida, Sofia Rodrigues, Débora Portuguese Laboratory Network for the Diagnosis of Influenza Infection |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Sáez-López, Emma Cristóvão, Paula Costa, Inês Pechirra, Pedro Conde, Patrícia Guiomar, Raquel Peres, Maria João Viseu, Regina Lopes, Paulo Soares, Vânia Vale, Fátima Fonseca, Patricia Freitas, Ludivina Alves, Jose Pessanha, Maria Ana Toscano, Cristina Mota-Vieira, Luísa Veloso, Rita Cabral Côrte-Real, Rita Branquinho, Paula Pereira‑Vaz, João Rodrigues, Fernando Cunha, Mário Martins, Luís Mota, Paula Couto, Ana Rita Bruges-Armas, Jácome Almeida, Sofia Rodrigues, Débora Portuguese Laboratory Network for the Diagnosis of Influenza Infection |
dc.subject.por.fl_str_mv |
Respiratory Syncytial Virus BA9 Genotype Genetic Diversity Molecular Epidemiology ON1 Genotype Portugal Infecções Respiratórias |
topic |
Respiratory Syncytial Virus BA9 Genotype Genetic Diversity Molecular Epidemiology ON1 Genotype Portugal Infecções Respiratórias |
description |
Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31707201/ |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-10 2019-10-10T00:00:00Z 2020-05-05T23:06:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6599 |
url |
http://hdl.handle.net/10400.18/6599 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Clin Virol. 2019 Dec;121:104200. doi: 10.1016/j.jcv.2019.104200. Epub 2019 Oct 10 1386-6532 10.1016/j.jcv.2019.104200 |
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info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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