A Rare Case of Spontaneous Remission and Relapse of a Primary Central Nervous System Lymphoma

• Autor(a) principal: Ramos, Rui
• Data de Publicação: 2018
• Outros Autores: Fernandes, João Soares, Almeida, Marta, Almeida, Rui
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10198
• topic: Central Nervous System Neoplasms/drug therapy; Central Nervous System Neoplasms/radiotherapy; Lymphoma/drug therapy; Lymphoma/radiotherapy; Linfoma/quimioterapia; Linfoma/radioterapia; Neoplasias do Sistema Nervoso Central/quimioterapia; Neoplasias do Sistema Nervoso Central/radioterapia

Primary central nervous system lymphoma remission after steroid treatment is a well-known phenomenon, but remission without any type of treatment is extremely rare. We present a rare case of spontaneous remission of a diffuse large B-cell lymphoma of the central nervous system as well as its subsequent reappearance in another location. The atypical presentation misled the neurosurgeons and neurologists, delaying diagnosis and treatment. The patient underwent brain biopsy after the relapse and started radiotherapy and chemotherapy with cytarabine + methotrexate + rituximab. As of 32 months after the diagnosis, the patient remained asymptomatic, with no focal neurological deficits and the disease in complete remission. A PubMed search of the literature up to June 2017 regarding spontaneous remission central nervous system lymphoma was also carried out.