Genotoxic assessment in different exposure groups working with antineoplastic agents

Detalhes bibliográficos
Autor(a) principal: Ladeira, Carina
Data de Publicação: 2015
Outros Autores: Viegas, Susana, Pádua, Mário, Carolino, Elisabete, Gomes, Manuel C., Brito, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/4889
Resumo: Antioneoplastic drugs are widely used in treatment of cancer, and several studies suggest acute and long-term effects associated to antineoplastic drug exposures, namely associating workplace exposure with health effects. Cytokinesis blocked micronucleus (CBMN) assay is one promising short-term genotoxicity assays for human risk assessment and their combination is recommended to monitor populations chronically exposed to genotoxic agents. The aim of this investigation is the genotoxicity assessment in different professionals that handle cytostatics drugs. This research is case-control blinded study constituted by 46 non-exposed subjects and 44 workers that handle antineoplastic drugs, such as pharmacists, pharmacy technicians, and nurses. It was found statistically significant increases in the genotoxicity biomarkers in exposed comparising with controls (p<0.05). The findings address the need for regular biomonitoring of personnel occupationally exposed to these drugs, confirming to an enhanced health risk assessment.
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spelling Genotoxic assessment in different exposure groups working with antineoplastic agentsOccupational healthGenotoxic assessmentAntineoplastic drugsCytostatic drugsAntioneoplastic drugs are widely used in treatment of cancer, and several studies suggest acute and long-term effects associated to antineoplastic drug exposures, namely associating workplace exposure with health effects. Cytokinesis blocked micronucleus (CBMN) assay is one promising short-term genotoxicity assays for human risk assessment and their combination is recommended to monitor populations chronically exposed to genotoxic agents. The aim of this investigation is the genotoxicity assessment in different professionals that handle cytostatics drugs. This research is case-control blinded study constituted by 46 non-exposed subjects and 44 workers that handle antineoplastic drugs, such as pharmacists, pharmacy technicians, and nurses. It was found statistically significant increases in the genotoxicity biomarkers in exposed comparising with controls (p<0.05). The findings address the need for regular biomonitoring of personnel occupationally exposed to these drugs, confirming to an enhanced health risk assessment.Taylor & FrancisRCIPLLadeira, CarinaViegas, SusanaPádua, MárioCarolino, ElisabeteGomes, Manuel C.Brito, Miguel2015-08-20T15:07:38Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/4889engLadeira C, Viegas S, Pádua M, Carolino E, Gomes MC, Brito M. Genotoxic assessment in different exposure groups working with antineoplastic agents. In Arezes PM, Baptista JS, Barroso MP, Carneiro P, Cordeiro P, Costa N, et al, editors. Occupational safety and hygiene III. London: Taylor & Francis; 2015. p. 177-80.10.1201/b18042-37info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:47:31Zoai:repositorio.ipl.pt:10400.21/4889Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:14:15.345425Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genotoxic assessment in different exposure groups working with antineoplastic agents
title Genotoxic assessment in different exposure groups working with antineoplastic agents
spellingShingle Genotoxic assessment in different exposure groups working with antineoplastic agents
Ladeira, Carina
Occupational health
Genotoxic assessment
Antineoplastic drugs
Cytostatic drugs
title_short Genotoxic assessment in different exposure groups working with antineoplastic agents
title_full Genotoxic assessment in different exposure groups working with antineoplastic agents
title_fullStr Genotoxic assessment in different exposure groups working with antineoplastic agents
title_full_unstemmed Genotoxic assessment in different exposure groups working with antineoplastic agents
title_sort Genotoxic assessment in different exposure groups working with antineoplastic agents
author Ladeira, Carina
author_facet Ladeira, Carina
Viegas, Susana
Pádua, Mário
Carolino, Elisabete
Gomes, Manuel C.
Brito, Miguel
author_role author
author2 Viegas, Susana
Pádua, Mário
Carolino, Elisabete
Gomes, Manuel C.
Brito, Miguel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Ladeira, Carina
Viegas, Susana
Pádua, Mário
Carolino, Elisabete
Gomes, Manuel C.
Brito, Miguel
dc.subject.por.fl_str_mv Occupational health
Genotoxic assessment
Antineoplastic drugs
Cytostatic drugs
topic Occupational health
Genotoxic assessment
Antineoplastic drugs
Cytostatic drugs
description Antioneoplastic drugs are widely used in treatment of cancer, and several studies suggest acute and long-term effects associated to antineoplastic drug exposures, namely associating workplace exposure with health effects. Cytokinesis blocked micronucleus (CBMN) assay is one promising short-term genotoxicity assays for human risk assessment and their combination is recommended to monitor populations chronically exposed to genotoxic agents. The aim of this investigation is the genotoxicity assessment in different professionals that handle cytostatics drugs. This research is case-control blinded study constituted by 46 non-exposed subjects and 44 workers that handle antineoplastic drugs, such as pharmacists, pharmacy technicians, and nurses. It was found statistically significant increases in the genotoxicity biomarkers in exposed comparising with controls (p<0.05). The findings address the need for regular biomonitoring of personnel occupationally exposed to these drugs, confirming to an enhanced health risk assessment.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-20T15:07:38Z
2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/4889
url http://hdl.handle.net/10400.21/4889
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ladeira C, Viegas S, Pádua M, Carolino E, Gomes MC, Brito M. Genotoxic assessment in different exposure groups working with antineoplastic agents. In Arezes PM, Baptista JS, Barroso MP, Carneiro P, Cordeiro P, Costa N, et al, editors. Occupational safety and hygiene III. London: Taylor & Francis; 2015. p. 177-80.
10.1201/b18042-37
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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