The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/83223 |
Resumo: | Infections are one of the most significant complications of neonates, especially those born preterm, with sepsis as one of the principal causes of mortality. Coagulase-negative staphylococci (CoNS), a group of staphylococcal species that naturally inhabit healthy human skin and mucosa, are the most common cause of late-onset sepsis, especially in preterms. One of the risk factors for the development of CoNS infections is the presence of implanted biomedical devices, which are frequently used for medications and/or nutrient delivery, as they serve as a scaffold for biofilm formation. The major concerns related to CoNS infections have to do with the increasing resistance to multiple antibiotics observed among this bacterial group and biofilm cells’ increased tolerance to antibiotics. As such, the treatment of CoNS biofilm-associated infections with antibiotics is increasingly challenging and considering that antibiotics remain the primary form of treatment, this issue will likely persist in upcoming years. For that reason, the development of innovative and efficient therapeutic measures is of utmost importance. This narrative review assesses the current challenges and emerging diagnostic tools and therapies for the treatment of CoNS biofilm-associated infections, with a special focus on late-onset sepsis. |
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The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapiesNeonatal sepsisLate-onset sepsisCoagulase-negative staphylococciDiagnosisTreatmentAntibiotic resistanceAntibiotic toleranceBiofilmsScience & TechnologyInfections are one of the most significant complications of neonates, especially those born preterm, with sepsis as one of the principal causes of mortality. Coagulase-negative staphylococci (CoNS), a group of staphylococcal species that naturally inhabit healthy human skin and mucosa, are the most common cause of late-onset sepsis, especially in preterms. One of the risk factors for the development of CoNS infections is the presence of implanted biomedical devices, which are frequently used for medications and/or nutrient delivery, as they serve as a scaffold for biofilm formation. The major concerns related to CoNS infections have to do with the increasing resistance to multiple antibiotics observed among this bacterial group and biofilm cells’ increased tolerance to antibiotics. As such, the treatment of CoNS biofilm-associated infections with antibiotics is increasingly challenging and considering that antibiotics remain the primary form of treatment, this issue will likely persist in upcoming years. For that reason, the development of innovative and efficient therapeutic measures is of utmost importance. This narrative review assesses the current challenges and emerging diagnostic tools and therapies for the treatment of CoNS biofilm-associated infections, with a special focus on late-onset sepsis.This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the project with the reference EXPL/BIA-MIC/0032/2021.info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoFrança, Ângela Maria Oliveira Sousa2023-03-062023-03-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/83223engFrança, Angela, The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies. Antibiotics, 12(3), 554, 20232079-63822079-638210.3390/antibiotics12030554554https://www.mdpi.com/2079-6382/12/3/554info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:19:44Zoai:repositorium.sdum.uminho.pt:1822/83223Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:12:43.045016Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies |
title |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies |
spellingShingle |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies França, Ângela Maria Oliveira Sousa Neonatal sepsis Late-onset sepsis Coagulase-negative staphylococci Diagnosis Treatment Antibiotic resistance Antibiotic tolerance Biofilms Science & Technology |
title_short |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies |
title_full |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies |
title_fullStr |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies |
title_full_unstemmed |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies |
title_sort |
The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies |
author |
França, Ângela Maria Oliveira Sousa |
author_facet |
França, Ângela Maria Oliveira Sousa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
França, Ângela Maria Oliveira Sousa |
dc.subject.por.fl_str_mv |
Neonatal sepsis Late-onset sepsis Coagulase-negative staphylococci Diagnosis Treatment Antibiotic resistance Antibiotic tolerance Biofilms Science & Technology |
topic |
Neonatal sepsis Late-onset sepsis Coagulase-negative staphylococci Diagnosis Treatment Antibiotic resistance Antibiotic tolerance Biofilms Science & Technology |
description |
Infections are one of the most significant complications of neonates, especially those born preterm, with sepsis as one of the principal causes of mortality. Coagulase-negative staphylococci (CoNS), a group of staphylococcal species that naturally inhabit healthy human skin and mucosa, are the most common cause of late-onset sepsis, especially in preterms. One of the risk factors for the development of CoNS infections is the presence of implanted biomedical devices, which are frequently used for medications and/or nutrient delivery, as they serve as a scaffold for biofilm formation. The major concerns related to CoNS infections have to do with the increasing resistance to multiple antibiotics observed among this bacterial group and biofilm cells’ increased tolerance to antibiotics. As such, the treatment of CoNS biofilm-associated infections with antibiotics is increasingly challenging and considering that antibiotics remain the primary form of treatment, this issue will likely persist in upcoming years. For that reason, the development of innovative and efficient therapeutic measures is of utmost importance. This narrative review assesses the current challenges and emerging diagnostic tools and therapies for the treatment of CoNS biofilm-associated infections, with a special focus on late-onset sepsis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-06 2023-03-06T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/83223 |
url |
https://hdl.handle.net/1822/83223 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
França, Angela, The role of coagulase-negative Staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies. Antibiotics, 12(3), 554, 2023 2079-6382 2079-6382 10.3390/antibiotics12030554 554 https://www.mdpi.com/2079-6382/12/3/554 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132563389808640 |