Peptides with dual antimicrobial and anticancer activities

Detalhes bibliográficos
Autor(a) principal: Felício, Mário R.
Data de Publicação: 2017
Outros Autores: Silva, Osmar N., Gonçalves, Sónia, Santos, Nuno C., Franco, Octávio L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/32820
Resumo: Copyright © 2017 Felício, Silva, Gonçalves, Santos and Franco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Peptides with dual antimicrobial and anticancer activitiesAnticancer peptides (ACPs)Antimicrobial peptides (AMPs)CancerMulti-resistant infectionsBacteriaCopyright © 2017 Felício, Silva, Gonçalves, Santos and Franco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.In recent years, the number of people suffering from cancer and multi-resistant infections has increased, such that both diseases are already seen as current and future major causes of death. Moreover, chronic infections are one of the main causes of cancer, due to the instability in the immune system that allows cancer cells to proliferate. Likewise, the physical debility associated with cancer or with anticancer therapy itself often paves the way for opportunistic infections. It is urgent to develop new therapeutic methods, with higher efficiency and lower side effects. Antimicrobial peptides (AMPs) are found in the innate immune system of a wide range of organisms. Identified as the most promising alternative to conventional molecules used nowadays against infections, some of them have been shown to have dual activity, both as antimicrobial and anticancer peptides (ACPs). Highly cationic and amphipathic, they have demonstrated efficacy against both conditions, with the number of nature-driven or synthetically designed peptides increasing year by year. With similar properties, AMPs that can also act as ACPs are viewed as future chemotherapeutic drugs, with the advantage of low propensity to resistance, which started this paradigm in the pharmaceutical market. These peptides have already been described as molecules presenting killing mechanisms at the membrane level, but also acting toward intracellular targets, which increases their success compartively to one-target specific drugs. This review will approach the desirable characteristics of small peptides that demonstrated dual activity against microbial infections and cancer, as well as the peptides engaged in clinical trials.This work was supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal), by Brazilian funding agencies CNPq, CAPES, FADPDF, FINEP, and FUNDECT, and by Marie Skłodowska-Curie, Research, and Innovation Staff Exchange (MSCA-RISE, European Union) project INPACT (call H2020-MSCA-RISE-2014, grant agreement 644167). MF acknowledges FCT-MCTES fellowship SPRH/BD/100517/2014. OS holds a postdoctoral scholarship from the National Council of Technological and Scientific Development (CNPq) and Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT; 300583/2016-8).Frontiers MediaRepositório da Universidade de LisboaFelício, Mário R.Silva, Osmar N.Gonçalves, SóniaSantos, Nuno C.Franco, Octávio L.2018-04-16T14:06:33Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/32820engFront. Chem. 5:52296-264610.3389/fchem.2017.00005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:27:12Zoai:repositorio.ul.pt:10451/32820Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:47:57.806288Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Peptides with dual antimicrobial and anticancer activities
title Peptides with dual antimicrobial and anticancer activities
spellingShingle Peptides with dual antimicrobial and anticancer activities
Felício, Mário R.
Anticancer peptides (ACPs)
Antimicrobial peptides (AMPs)
Cancer
Multi-resistant infections
Bacteria
title_short Peptides with dual antimicrobial and anticancer activities
title_full Peptides with dual antimicrobial and anticancer activities
title_fullStr Peptides with dual antimicrobial and anticancer activities
title_full_unstemmed Peptides with dual antimicrobial and anticancer activities
title_sort Peptides with dual antimicrobial and anticancer activities
author Felício, Mário R.
author_facet Felício, Mário R.
Silva, Osmar N.
Gonçalves, Sónia
Santos, Nuno C.
Franco, Octávio L.
author_role author
author2 Silva, Osmar N.
Gonçalves, Sónia
Santos, Nuno C.
Franco, Octávio L.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Felício, Mário R.
Silva, Osmar N.
Gonçalves, Sónia
Santos, Nuno C.
Franco, Octávio L.
dc.subject.por.fl_str_mv Anticancer peptides (ACPs)
Antimicrobial peptides (AMPs)
Cancer
Multi-resistant infections
Bacteria
topic Anticancer peptides (ACPs)
Antimicrobial peptides (AMPs)
Cancer
Multi-resistant infections
Bacteria
description Copyright © 2017 Felício, Silva, Gonçalves, Santos and Franco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2018-04-16T14:06:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/32820
url http://hdl.handle.net/10451/32820
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front. Chem. 5:5
2296-2646
10.3389/fchem.2017.00005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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