Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation

Detalhes bibliográficos
Autor(a) principal: Campos, Ana M. F. Oliveira
Data de Publicação: 2008
Outros Autores: Sivasubramanian, Aravind, Rodrigues, Lígia M., Seijas, Julio A., Vázquez-Tato, M. Pilar, Peixoto, Francisco, Abreu, Carlos G., Cidade, Honorina, Oliveira, Ana Elizabete, Pinto, Madalena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/8648
Resumo: A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and in two cases by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.
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spelling Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluationPyrazolo-pyrimidinesAntifungalXanthine oxidaseScience & TechnologyA simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and in two cases by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.FEDERFundação para a Ciência e Tecnologia (FCT) - I&D 226/2003, POCTI-SFA-3-686), SFRH/BPD/20816/ 2004)Xunta de Galicia - PGIDIT05PXIB26201PR,PR405A098/59-0WileyUniversidade do MinhoCampos, Ana M. F. OliveiraSivasubramanian, AravindRodrigues, Lígia M.Seijas, Julio A.Vázquez-Tato, M. PilarPeixoto, FranciscoAbreu, Carlos G.Cidade, HonorinaOliveira, Ana ElizabetePinto, Madalena2008-072008-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/8648eng"Helvetica Chimica Acta." ISSN 0018-019X. 91:7 (Jul. 2008) 1336-1345.0018-019X10.1002/hlca.200890145www.interscience.wiley.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:30:25Zoai:repositorium.sdum.uminho.pt:1822/8648Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:25:35.252656Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
title Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
spellingShingle Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
Campos, Ana M. F. Oliveira
Pyrazolo-pyrimidines
Antifungal
Xanthine oxidase
Science & Technology
title_short Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
title_full Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
title_fullStr Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
title_full_unstemmed Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
title_sort Substituted pyrazolo[3,4-d]pyrimidines : microwave assisted, solvent free synthesis and biological evaluation
author Campos, Ana M. F. Oliveira
author_facet Campos, Ana M. F. Oliveira
Sivasubramanian, Aravind
Rodrigues, Lígia M.
Seijas, Julio A.
Vázquez-Tato, M. Pilar
Peixoto, Francisco
Abreu, Carlos G.
Cidade, Honorina
Oliveira, Ana Elizabete
Pinto, Madalena
author_role author
author2 Sivasubramanian, Aravind
Rodrigues, Lígia M.
Seijas, Julio A.
Vázquez-Tato, M. Pilar
Peixoto, Francisco
Abreu, Carlos G.
Cidade, Honorina
Oliveira, Ana Elizabete
Pinto, Madalena
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Campos, Ana M. F. Oliveira
Sivasubramanian, Aravind
Rodrigues, Lígia M.
Seijas, Julio A.
Vázquez-Tato, M. Pilar
Peixoto, Francisco
Abreu, Carlos G.
Cidade, Honorina
Oliveira, Ana Elizabete
Pinto, Madalena
dc.subject.por.fl_str_mv Pyrazolo-pyrimidines
Antifungal
Xanthine oxidase
Science & Technology
topic Pyrazolo-pyrimidines
Antifungal
Xanthine oxidase
Science & Technology
description A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and in two cases by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
2008-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/8648
url http://hdl.handle.net/1822/8648
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Helvetica Chimica Acta." ISSN 0018-019X. 91:7 (Jul. 2008) 1336-1345.
0018-019X
10.1002/hlca.200890145
www.interscience.wiley.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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