Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines

Detalhes bibliográficos
Autor(a) principal: Kuhn,Bruna P.
Data de Publicação: 2015
Outros Autores: Malavolta,Juliana L., Casagrande,Gleison A., Raminelli,Cristiano, Quina,Frank H., Pereira,Claudio M. P., Flores,Alex F. C., Pizzuti,Lucas
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601306
Resumo: A series of twelve novel 2-(pyrazol-1-yl)pyrimidine derivatives was easily obtained under ultrasonic conditions by the cyclocondensation reaction of 1-carboxamidino-pyrazoles with 4-methoxyvinyl-trifluoromethyl ketones using ethanol as an environment-friendly solvent in the presence of potassium hydroxide. Comparison of the ultrasound-promoted reaction with classical methodology shows that the former is faster and gives better yield. The products were isolated in excellent purity grades without purification by chromatography or recrystalization.
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spelling Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines2-(4,5-dihydro-1H-pyrazol-1-yl)pyrimidinespyrazolylpyrimidinessonochemistrypyrimidinespyrazolesA series of twelve novel 2-(pyrazol-1-yl)pyrimidine derivatives was easily obtained under ultrasonic conditions by the cyclocondensation reaction of 1-carboxamidino-pyrazoles with 4-methoxyvinyl-trifluoromethyl ketones using ethanol as an environment-friendly solvent in the presence of potassium hydroxide. Comparison of the ultrasound-promoted reaction with classical methodology shows that the former is faster and gives better yield. The products were isolated in excellent purity grades without purification by chromatography or recrystalization.Sociedade Brasileira de Química2015-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601306Journal of the Brazilian Chemical Society v.26 n.6 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150078info:eu-repo/semantics/openAccessKuhn,Bruna P.Malavolta,Juliana L.Casagrande,Gleison A.Raminelli,CristianoQuina,Frank H.Pereira,Claudio M. P.Flores,Alex F. C.Pizzuti,Lucaseng2020-06-05T00:00:00Zoai:scielo:S0103-50532015000601306Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2020-06-05T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
title Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
spellingShingle Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
Kuhn,Bruna P.
2-(4,5-dihydro-1H-pyrazol-1-yl)pyrimidines
pyrazolylpyrimidines
sonochemistry
pyrimidines
pyrazoles
title_short Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
title_full Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
title_fullStr Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
title_full_unstemmed Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
title_sort Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines
author Kuhn,Bruna P.
author_facet Kuhn,Bruna P.
Malavolta,Juliana L.
Casagrande,Gleison A.
Raminelli,Cristiano
Quina,Frank H.
Pereira,Claudio M. P.
Flores,Alex F. C.
Pizzuti,Lucas
author_role author
author2 Malavolta,Juliana L.
Casagrande,Gleison A.
Raminelli,Cristiano
Quina,Frank H.
Pereira,Claudio M. P.
Flores,Alex F. C.
Pizzuti,Lucas
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kuhn,Bruna P.
Malavolta,Juliana L.
Casagrande,Gleison A.
Raminelli,Cristiano
Quina,Frank H.
Pereira,Claudio M. P.
Flores,Alex F. C.
Pizzuti,Lucas
dc.subject.por.fl_str_mv 2-(4,5-dihydro-1H-pyrazol-1-yl)pyrimidines
pyrazolylpyrimidines
sonochemistry
pyrimidines
pyrazoles
topic 2-(4,5-dihydro-1H-pyrazol-1-yl)pyrimidines
pyrazolylpyrimidines
sonochemistry
pyrimidines
pyrazoles
description A series of twelve novel 2-(pyrazol-1-yl)pyrimidine derivatives was easily obtained under ultrasonic conditions by the cyclocondensation reaction of 1-carboxamidino-pyrazoles with 4-methoxyvinyl-trifluoromethyl ketones using ethanol as an environment-friendly solvent in the presence of potassium hydroxide. Comparison of the ultrasound-promoted reaction with classical methodology shows that the former is faster and gives better yield. The products were isolated in excellent purity grades without purification by chromatography or recrystalization.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601306
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601306
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150078
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.26 n.6 2015
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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